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dc.contributor.authorAras, Yavuz
dc.contributor.authorSabancı, Pulat Akın
dc.contributor.authorKabataş, Serdar
dc.contributor.authorDuruksu, Gökhan
dc.contributor.authorSubası, Cansu
dc.contributor.authorErguvan, Mine
dc.contributor.authorKaragöz, Erdal
dc.date.accessioned2020-12-02T18:12:02Z
dc.date.available2020-12-02T18:12:02Z
dc.date.issued2016
dc.identifier.issn1019-5149
dc.identifier.urihttps://app.trdizin.gov.tr//makale/TWpFd016UXlNZz09
dc.identifier.urihttp://hdl.handle.net/11446/4227
dc.description.abstractAIM: To investigate the effectiveness of rat adipose tissue-derived (rAT) mesenchymal stem cell (MSC) transplantation on the functional restoration and regeneration of spinal cord injury (SCI).MATERIAl and METhODS: Six of 48 Wistar albino rats were sacrificed to obtain MSCs, and the remaining rats were divided randomly into six groups. SCI was performed using the clip compression method. The control and transplantation groups were injected with physiological saline and a rAT-MSC suspension at the injury sites, respectively. Each animal was evaluated using the Basso, Beattie and Bresnahan (BBB) rating system and sacrificed at 28 days post-injury period (p.i.). The regeneration process was evaluated based on immunostaining against ?3-tubulin, BDNF, CNTF, and CNPase. RESulTS: rAT-MSC transplantation into the SCI site substantially improved the tissue regeneration and functional recovery (p < 0.05). However, the rAT-MSC transplantation at 9 days p.i. was not more efficient on functional recovery than the transplantation immediately after injury. The expression of ?3-tubulin, BDNF and CNTF at the injury site indicated the potential for functional regeneration. COnCluSIOn: The adaptive nature of rat-MSCs enabled the remodulation and regeneration of the lesion site, decreasing the importance of transplantation time in the treatment of SCIen_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.titleThe Effects of Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation During the Acute and Subacute Phases Following Spinal Cord Injuryen_US
dc.typearticleen_US
dc.relation.journalTurkish Neurosurgeryen_US
dc.departmentDBÜen_US
dc.identifier.issue1en_US
dc.identifier.volume26en_US
dc.identifier.startpage127en_US
dc.identifier.endpage139en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-tempİstanbul Üniversitesi, İstanbul Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye;İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye;Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Rize, Türkiye;Boş;Boş;Boş;Boşen_US


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