dc.contributor.author | Akcil, E.F. | |
dc.contributor.author | Korkmaz Dilmen, O. | |
dc.contributor.author | Ertem, Vehid, H. | |
dc.contributor.author | Yentur, E. | |
dc.contributor.author | Tunali, Y. | |
dc.date.accessioned | 2021-06-10T19:38:19Z | |
dc.date.available | 2021-06-10T19:38:19Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0300-7995 | |
dc.identifier.uri | https://doi.org/10.1080/03007995.2018.1501352 | |
dc.identifier.uri | http://hdl.handle.net/11446/4290 | |
dc.description | PubMed: 30010438 | en_US |
dc.description | 2-s2.0-85052082909 | en_US |
dc.description.abstract | Objective: Morphine is commonly used in post-operative analgesia, but opioid-related respiratory depression causes a general reluctance for its use. The “Integrated Pulmonary Index” is a tool calculated from non-invasively obtained respiratory and hemodynamic parameters. The aim of this prospective, randomized, double blind, and placebo-controlled study is to determine a more safe and effective dose for morphine in patient-controlled analgesia following supratentorial craniotomy using the “Integrated Pulmonary Index”. Methods: This study included 60 patients (ASA I, II, and III). All patients used iv PCA for 24 h following supratentorial craniotomy. The PCA was set to administer a bolus dose of 1 mg morphine in Group 1 and 0.5 mg morphine in Group 2. The PCA contained placebo in Group 3 and patients received dexketoprofen 50 mg iv after awakening, repeated every 8 h. The IPI and NRS scores, total morphine consumption, and morphine related side-effects were recorded at 10 min, 1, 2, 6, 12, and 24 h post-operatively. The lowest IPI score, count of apnea, and desaturation events were recorded during the study period. Results: The IPI scores were similar among the groups. Although a statistically significant difference was not observed among the groups the lowest IPI scores were observed in Group 1; apnea and desaturation counts were also higher in Group 1. Statistically significant differences were not observed among the groups in terms of pain scores, but were lower in Groups 1 and 2 compared to Group 3. Conclusion: Patient controlled analgesia with 0.5 mg morphine may be safe and effective for pain management following supratentorial craniotomies. Integrated pulmonary index can be used for detecting opioid-induced respiratory depression. Clinical Trials registration number: NCT02929147. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor and Francis Ltd | en_US |
dc.identifier.doi | 10.1080/03007995.2018.1501352 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Integrated pulmonary index | en_US |
dc.subject | Morphine | en_US |
dc.subject | Patient controlled analgesia | en_US |
dc.subject | Supratentorial craniotomy | en_US |
dc.title | The role of “Integrated Pulmonary Index” monitoring during morphine-based intravenous patient-controlled analgesia administration following supratentorial craniotomies: a prospective, randomized, double-blind controlled study | en_US |
dc.type | article | en_US |
dc.relation.journal | Current Medical Research and Opinion | en_US |
dc.department | [0-Belirlenecek] | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.volume | 34 | en_US |
dc.identifier.startpage | 2009 | en_US |
dc.identifier.endpage | 2014 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.institutionauthor | [0-Belirlenecek] | |
dc.department-temp | Akcil, E.F., Department of Anesthesiology and Intensive Care, Cerrahpasa School of Medicine, University of Istanbul, Turkey; Korkmaz Dilmen, O., Department of Anesthesiology and Intensive Care, Cerrahpasa School of Medicine, University of Istanbul, Turkey; Ertem Vehid, H., Department of Medical Education and Informatics, University of Istanbul Bilim, Turkey; Yentur, E., Department of Anesthesiology and Intensive Care, University of Istanbul Bilim, Turkey; Tunali, Y., Department of Anesthesiology and Intensive Care, Cerrahpasa School of Medicine, University of Istanbul, Turkey | en_US |