dc.contributor.author | Sahin, Cagdas | |
dc.contributor.author | Yıldırım, Nuri | |
dc.contributor.author | Hortu, İsmail | |
dc.contributor.author | Akdemir, Ali Osman | |
dc.contributor.author | Özşener, Serdar | |
dc.contributor.author | Yiğittürk, Gürkan | |
dc.contributor.author | Erbaş, Oytun | |
dc.date.accessioned | 2021-06-10T19:38:22Z | |
dc.date.available | 2021-06-10T19:38:22Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1309-0399 | |
dc.identifier.issn | 1309-0380 | |
dc.identifier.uri | https://doi.org/10.4274/jtgga.galenos.2019.2018.0121 | |
dc.identifier.uri | https://app.trdizin.gov.tr/makale/TXpnMU5ESTBOQT09 | |
dc.identifier.uri | http://hdl.handle.net/11446/4313 | |
dc.description.abstract | Objective: Tadalafil is a selective phosphodiesterase type-5 inhibitor with a long half-life. It has a dual function in ischaemic and re-perfused tissues, i.e. vasodilatation and anti-oxidant effects. These features of tadalafil distinguish it from other anti-oxidants. We investigated the dual effect of tadalafil on ischaemia and reperfusion injury in the rat ovary. Material and Methods: We established five study groups. Group 1 (n=6): sham-operated; group 2 (n=6): torsion; group 3 (n=6): torsion and Tadalafil; group 4 (n=6): torsion/de-torsion; and group 5 (n=6): torsion/de-torsion and tadalafil. Ovarian samples were harvested from animals and evaluated in terms of histopathologic changes, tissue malondialdehyde (MDA) concentrations, lactate production, and plasma cyclic guanosine monophosphate (cGMP). Results: Follicular degeneration, oedema, haemorrhage, and inflammatory cells were significantly decreased in group 5 in comparison with group 4. Group 2 and group 3 were compared in terms of vascular congestion and haemorrhage; these parameters were significantly decreased in group 3. In addition, significantly decreased MDA and lactate concentrations were observed in group 5 in comparison with group 4. Increased cGMP concentrations were detected in group 3 and group 5. Conclusion: We conclude that tadalafil might be useful in protecting the ovary against ischaemia and reperfusion injury. In the evet of ovarian torsion, it will provide a greater therapeutic effect than only performing de-torsion of the ovary or using other anti-oxidant agents. (J Turk Ger Gynecol Assoc 2020; 21: 35-40) | en_US |
dc.language.iso | eng | en_US |
dc.identifier.doi | 10.4274/jtgga.galenos.2019.2018.0121 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.title | Tadalafil attenuates ischemic damage as well as reperfusion injury in the rat ovary | en_US |
dc.type | Diğer | en_US |
dc.relation.journal | Journal of the Turkish-German Gynecological Association | en_US |
dc.department | [0-Belirlenecek] | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.volume | 21 | en_US |
dc.identifier.startpage | 35 | en_US |
dc.identifier.endpage | 40 | en_US |
dc.relation.publicationcategory | Diğer | en_US |
dc.institutionauthor | [0-Belirlenecek] | |
dc.department-temp | Ege Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, İzmir, Türkiye;Ege Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, İzmir, Türkiye;Ege Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, İzmir, Türkiye;Ege Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, İzmir, Türkiye;Ege Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, İzmir, Türkiye;Muğla Sıtkı Koçman Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Muğla, Türkiye;Demiroğlu Bilim Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, İstanbul, Türkiye | en_US |