dc.contributor.author | Nalbantoglu, Mecbure | |
dc.contributor.author | Akalin, Mehmet Ali | |
dc.contributor.author | Gunduz, Aysegul | |
dc.contributor.author | Kiziltan, Meral | |
dc.date.accessioned | 2021-06-10T19:38:28Z | |
dc.date.available | 2021-06-10T19:38:28Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0019-1442 | |
dc.identifier.issn | 2498-6208 | |
dc.identifier.uri | https://doi.oeg/10.18071/isz.74.0033 | |
dc.identifier.uri | http://hdl.handle.net/11446/4343 | |
dc.description | PubMed: 33497057 | en_US |
dc.description | WOS:000616691000004 | en_US |
dc.description.abstract | Background and purpose - Myasthenia gravis (MG) is an autoimmune disorder of neuromuscular transmission. Autonomic dysfunction is not a commonly known association with MG. We conducted this study to evaluate autonomic functions in MG & subgroups and to investigate the effects of acetylcholinesterase inhibitors. Methods - This study comprised 30 autoimmune MG patients and 30 healthy volunteers. Autonomic tests including sympathetic skin response (SSR) and R-R interval variation analysis (RRIV) was carried out. The tests were performed two times for patients who were under acetylcholinesterase inhibitors during the current assessment. Results - The RRIV rise during hyperventilation was better (p=0.006) and Valsalva ratio (p=0.039) was lower in control group. The SSR amplitudes were lower thereafter drug intake (p=0.030). As much as time went by after drug administration prolonged SSR latencies were obtained (p=0.043).Valsalva ratio was lower in the AchR antibody negative group (p=0.033). Conclusion - The findings showed that both ocular/generalized MG patients have a subclinical parasympathetic abnormality prominent in the AchR antibody negative group and pyridostigmine has a peripheral sympathetic cholinergic noncumulative effect. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Literatura Medica | en_US |
dc.identifier.doi | 10.18071/isz.74.0033 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | myasthenia gravis | en_US |
dc.subject | autonomic dysfunction | en_US |
dc.subject | sympathetic skin response | en_US |
dc.subject | R-R interval variation analysis | en_US |
dc.subject | anticholinesterase inhibitors | en_US |
dc.subject | pyridostigmine | en_US |
dc.title | ELECTROPHYSIOLOGICAL INVESTIGATION FOR AUTONOMIC DYSFUNCTION IN PATIENTS WITH MYASTHENIA GRAVIS: A PROSPECTIVE STUDY | en_US |
dc.type | article | en_US |
dc.relation.journal | Ideggyogyaszati Szemle-Clinical Neuroscience | en_US |
dc.department | [0-Belirlenecek] | en_US |
dc.identifier.issue | 1-2 | en_US |
dc.identifier.volume | 74 | en_US |
dc.identifier.startpage | 33 | en_US |
dc.identifier.endpage | 40 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.institutionauthor | [0-Belirlenecek] | |
dc.department-temp | [Nalbantoglu, Mecbure] Demiroglu Bilim Univ, Neurol Dept, Med Fac, Istanbul, Turkey; [Akalin, Mehmet Ali] Mem Bahcelievler Hosp, Neurol Dept, Istanbul, Turkey; [Gunduz, Aysegul; Kiziltan, Meral] Istanbul Univ, Neurol Dept, Cerrahpasa Med Fac, Istanbul, Turkey | en_US |