dc.description.abstract | Purpose To evaluate the outcomes of metastasis-directed treatment (MDT) using stereotactic body radiotherapy (SBRT) for bone-only oligometastasis (OM) detected with gallium prostate-specific membrane antigen (Ga-68-PSMA) PET/CT in castration-sensitive prostate cancer (PC) patients. Methods In this multi-institutional study, clinical data of 74 PC patients with 153 bone lesions who were undergoing MDT were retrospectively evaluated. Twenty-seven patients (36.5%) had synchronous, and 47 (63.5%) had metachronous OM. All patients had PC with 5 metastases or fewer detected by Ga-68-PSMA PET/CT and treated using SBRT with a median dose of 20 Gy. The prognostic factors for PC-specific survival (PCSS) and progression-free survival (PFS) were analyzed. Results The median follow-up was 27.3 months. Patients with synchronous OM were older and received higher rates of androgen deprivation therapy after SBRT compared with patients with metachronous OM. The 2-year PCSS and PFS rates were 92.0% and 72.0%, respectively. A prostate-specific antigen (PSA) decline was observed in 56 patients (75.7%), and 48 (64.9%) had a PSA response defined as at least 25% decrease of PSA after MDT. The 2-year local control rate per lesion was 95.4%. In multivariate analysis, single OM and PSA response after MDT were significant predictors for better PCSS and PFS. In-field recurrence was observed in 4 patients (6.5%) with 10 lesions at a median of 13.1 months after MDT completion. No serious late toxicity was observed. Conclusions We demonstrated that SBRT is an efficient and well-tolerated treatment option for PC patients with 5 bone-only oligometastases or fewer detected with Ga-68-PSMA PET/CT. | en_US |
dc.department-temp | [Onal, Cem; Guler, Ozan Cem] Baskent Univ, Fac Med, Dept Radiat Oncol, Adana Dr Turgut Noyan Res & Treatment Ctr, TR-01120 Adana, Turkey; [Ozyigit, Gokhan; Hurmuz, Pervin; Akyol, Fadil] Hacettepe Univ, Fac Med, Dept Radiat Oncol, Ankara, Turkey; [Akgun, Zuleyha] Mem Sisli Hosp, Div Radiat Oncol, Istanbul, Turkey; [Atalar, Banu; Mustafayev, Teuto Zoto] Acibadem MAA Univ, Maslak Hosp, Dept Radiat Oncol, Istanbul, Turkey; [Igdem, Sefik] Istanbul Bilim Univ, Dept Radiat Oncol, Istanbul, Turkey; [Oymak, Ezgi] Iskenderun Gelisim Hosp, Div Radiat Oncol, Antakya, Turkey; [Agaoglu, Fulya] Acibadem MAA Univ, Atakent Hosp, Dept Radiat Oncol, Istanbul, Turkey; [Selek, Ugur] Koc Univ, Sch Med, Dept Radiat Oncol, Istanbul, Turkey | en_US |