11β HSD-1 and PAI-1 gene expression fructose induced metabolic syndrome rats

Abstract

Backround: Metabolic syndrome (MetS) is an important health issue worldwide. It is a prevalent and complex disease, characterized by the variable coexistence of obesity, dyslipidemia, hyperinsulinaemia, and hypertension. The alarming rise in the prevalence of metabolic disorders makes it imperative to innovate preventive or therapeutic measures for MetS and its complications. However, the elucidation of the pathogenesis of MetS has been hampered by the lack of realistic models. In recent years, high comsumption of fructose has been shown to be an important factor of MetS. And, the presence and the increased level of expressions of 11β HSD-1 and PAI-1 genes in MetS were also shown to play an important role in the pathogenesis of MetS. Aim: The aim of this study was to investigate the effect of 20% fructose in the development of MetS in rats by the use of the biochemical and genetics approaches. Material and Metods: The study group was composed of MetS groups (n=10 rats) who were fed with water containing 20% fructose and control groups (n=10 rats) who were fed with only water for 15 weeks. Serum levels of glucose, insulin, total cholesterol, LDL, HDL, VLDL, ALT, AST, CRP and cortisol wer