dc.contributor.author | Comlek, Savas | |
dc.contributor.author | Saglam, Sezer | |
dc.date.accessioned | 2022-01-29T16:52:17Z | |
dc.date.available | 2022-01-29T16:52:17Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0004-282X | |
dc.identifier.issn | 1678-4227 | |
dc.identifier.uri | https://doi.org/10.1590/0004-282X-ANP-2020-0554 | |
dc.identifier.uri | http://hdl.handle.net/11446/4412 | |
dc.description.abstract | Background: Intrathecal chemotherapy is a local therapeutic modality used for treatment of leptomeningeal metastases. However, the techniques currently used, i.e. repeated lumbar puncture and Ommaya reservoir, have certain disadvantages. Lumbar intrathecal port (LIP) placement is a relatively novel technique, which has been used for pain management in cancer patients. Objective: To investigate the use of LIP for intrathecal administration of chemotherapeutic agents in patients with leptomeningeal metastases. Methods: Retrospective study of 13 patients treated with intrathecal chemotherapy for secondary leptomeningeal involvement of a primary solid tumor were included in this retrospective study. The patients received intrathecal chemotherapy through a LIP. Results: The patients received a total of 123 intrathecal chemotherapy doses. No grade 3-4 toxicity, technical problem or severe complication developed. During a median of 136 days of follow-up (range, 67-376 days), 12 patients died (92.3%). The treatment resulted in symptom improvement in all patients and self-rated overall health and quality of life improved, compared with baseline. Conclusions: The LIP system, which has been used for intrathecal pain management for decades, appears to offer a safe alternative for intrathecal chemotherapy in patients with leptomeningeal metastases. Further studies are warranted to clarify its potential use in this setting. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Assoc Arquivos Neuro- Psiquiatria | en_US |
dc.identifier.doi | 10.1590/0004-282X-ANP-2020-0554 | |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Neoplasm Metastasis | en_US |
dc.subject | Meningeal Carcinomatosis | en_US |
dc.subject | Injections | en_US |
dc.subject | Spinal | en_US |
dc.subject | Drug Therapy | en_US |
dc.subject | Spinal Puncture | en_US |
dc.subject | Cell Lung-Cancer | en_US |
dc.subject | Intraventricular Chemotherapy | en_US |
dc.subject | Cerebrospinal-Fluid | en_US |
dc.subject | Pain | en_US |
dc.subject | Carcinomatosis | en_US |
dc.subject | Survival | en_US |
dc.subject | Methotrexate | en_US |
dc.subject | Cytarabine | en_US |
dc.subject | Placement | en_US |
dc.subject | Catheters | en_US |
dc.title | A new approach for leptomeningeal metastases: chemotherapy administered through lumbar intrathecal port | en_US |
dc.type | article | en_US |
dc.relation.journal | Arquivos De Neuro-Psiquiatria | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.volume | 79 | en_US |
dc.identifier.startpage | 816 | en_US |
dc.identifier.endpage | 823 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Comlek, Savas] Gayrettepe Florence Nightingale Hastanesi, Dept Anesthesiol & Reanimat, Istanbul, Turkey; [Saglam, Sezer] Demiroglu Bilim Univ, Dept Med Oncol, Istanbul, Turkey | en_US |