dc.contributor.author | Gurkan, Gokhan | |
dc.contributor.author | Erdogan, Mumin Alper | |
dc.contributor.author | Yigitturk, Gurkan | |
dc.contributor.author | Erbas, Oytun | |
dc.date.accessioned | 2022-01-29T16:52:20Z | |
dc.date.available | 2022-01-29T16:52:20Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 2005-3711 | |
dc.identifier.issn | 1598-7876 | |
dc.identifier.uri | https://doi.org/10.3340/jkns.2021.0078 | |
dc.identifier.uri | http://hdl.handle.net/11446/4434 | |
dc.description.abstract | Objective : Peripheral nerve injuries occur mostly as a result of mechanical trauma. Due to the microvascular deterioration in peripheral nerve damage, it becomes challenging to remove free oxygen radicals. Gallic acid is a powerful antioxidant with anti-inf-lammatory effects and a free radical scavenger. The purpose of the study is to show that gallic acid contributes to the restorative effect in mechanical nerve damage, considering its antioxidant and anti-inflammatory effects. Methods : Thirty male Sprague Dawley albino mature rats were included in the study. Ten of them constituted the control group, 10 out of 20 rats for which sciatic nerve damage was caused, constituted the saline group, and 10 formed the gallic acid group. Post-treatment motor functions, histological, immunohistochemical, and biochemical parameters of the rats were evaluated. Results : Compared to the surgery+saline group, lower compound muscle action potential (CMAP) latency, higher CMAP amplitu-de, and higher inclined plane test values were found in the surgery+gallic acid group. Similarly, a higher nerve growth factor (NGF) percentage, a higher number of axons, and a lower percentage of fibrosis scores were observed in the surgery+gallic acid group. Fi-nally, lower tissue malondialdehyde (MDA) and higher heat shock protein-70 (HSP-70) values were determined in the surgery+gallic acid group. Conclusion : Gallic acid positively affects peripheral nerve injury healing due to its anti-inflammatory and antioxidant effects. It has been thought that gallic acid can be used as a supportive treatment in peripheral nerve damage. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Korean Neurosurgical Soc | en_US |
dc.identifier.doi | 10.3340/jkns.2021.0078 | |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Gallic acid | en_US |
dc.subject | Peripheral nerve injuries | en_US |
dc.subject | Experimental animal models | en_US |
dc.subject | Sciatic nerve | en_US |
dc.subject | Antioxidant Activity | en_US |
dc.subject | Injury | en_US |
dc.subject | Regeneration | en_US |
dc.subject | Pain | en_US |
dc.subject | Conduits | en_US |
dc.subject | Motor | en_US |
dc.title | The Restorative Effect of Gallic Acid on the Experimental Sciatic Nerve Damage Model | en_US |
dc.type | article | en_US |
dc.relation.journal | Journal Of Korean Neurosurgical Society | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.volume | 64 | en_US |
dc.identifier.startpage | 873 | en_US |
dc.identifier.endpage | 881 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Gurkan, Gokhan] Katip Celebi Univ Ataturk Training & Res Hosp, Dept Neurosurg, Basin Sitesi Mah Hasan Tahsin St 143, TR-35150 Izmir, Turkey; [Erdogan, Mumin Alper] Katip Celebi Univ, Fac Med, Dept Physiol, Izmir, Turkey; [Yigitturk, Gurkan] Sitki Kocman Univ, Fac Med, Dept Histol, Mugla, Turkey; [Erbas, Oytun] Istanbul Bilim Univ, Dept Physiol, Fac Med, Istanbul, Turkey | en_US |
dc.authorid | Erdogan, Mumin/0000-0003-0048-444X | |