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dc.contributor.authorCevik, Mehtap
dc.contributor.authorNamal, Esat
dc.contributor.authorSener, Nur Dinc
dc.contributor.authorKoksal, Ulkuhan Iner
dc.contributor.authorDeliorman, Gokce
dc.contributor.authorCiftci, Cavlan
dc.contributor.authorSusleyici, Belgin
dc.date.accessioned2022-01-29T16:52:20Z
dc.date.available2022-01-29T16:52:20Z
dc.date.issued2021
dc.identifier.issn2452-0144
dc.identifier.urihttps://doi.org/10.1016/j.genrep.2021.101279
dc.identifier.urihttp://hdl.handle.net/11446/4436
dc.description.abstractBackground: Since metastasis is one of the leading causes of high mortality in colorectal cancer, uncovering the molecular mechanisms underlying metastatic process has become important to find new treatment approaches. With this perspective, in this study we investigated effects of epithelial-mesenchymal transition (EMT) inducer SNAI1 rs6125849 gene polymorphism on different features of colorectal cancer. Material and methods: A total of 141 Turkish subjects consisting of 72 colorectal cancer patients and 69 healthy controls were included in the study. SNAI1 rs6125849 genotype analyses were performed with Agena MassARRAY platform. Results: We did not find any significant difference between case and control groups for rs6125849 genotypes. All metastatic patients were detected to have homozygous mutant (AA) genotype. Heterozygous and homozygous mutant genotypes (GA + AA) were more common in metastatic colorectal cancer patients compared to those with homozygous wild type (GG) genotype (p = 0.066). We also detected positive, albeit low but significant correlation between rs6125849 genotypes in codominant and dominant models (r = 0.250, p = 0.034 and r = 0.234, p = 0.048, respectively). Overall survival times was found to be considerably higher patients with A allele (Log rank: 3.04, p = 0.081). Conclusion: According to our preliminary results, we may speculate that SNAI1 gene G > A variation may result with a metastatic phenotype and shorter overall survival. Due to limited number of patients in our study group, further in vitro and in vivo studies are required to understand the role of SNAI1 rs6125849 variation on metastasis and survival functions.en_US
dc.description.sponsorshipMarmara University Scientific Research Projects Coordination UnitMarmara University [FEN-C-DRP-110718-0407]en_US
dc.description.sponsorshipThis study was supported by Marmara University Scientific Research Projects Coordination Unit. Project No: FEN-C-DRP-110718-0407.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.genrep.2021.101279
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSNAI1en_US
dc.subjectrs6125849en_US
dc.subjectColorectal Canceren_US
dc.subjectGene polymorphismen_US
dc.subjectMetastasisen_US
dc.subjectEpithelial-Mesenchymal Transitionen_US
dc.subjectE-Cadherin Expressionen_US
dc.subjectTranscriptional Repressor Snailen_US
dc.subjectTumor-Growthen_US
dc.subjectBreast-Carcinomaen_US
dc.subjectEmten_US
dc.subjectInvasionen_US
dc.subjectProgressionen_US
dc.subjectAllianceen_US
dc.subjectDominanten_US
dc.titleThe effects of SNAI1 rs6125849 gene polymorphism on metastasis and survival in colorectal cancer: Preliminary results from Turkish subjectsen_US
dc.typearticleen_US
dc.relation.journalGene Reportsen_US
dc.contributor.departmentDBÜen_US
dc.identifier.volume24en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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