dc.contributor.author | Görmüş, Uzay | |
dc.contributor.author | Timirci-Kahraman, Özlem | |
dc.contributor.author | Toptaş, Bahar | |
dc.contributor.author | İsbir, Turgay | |
dc.contributor.author | Çiftçi, Çavlan | |
dc.contributor.author | Berkkan, Hasan Hakan | |
dc.contributor.author | Karatay, Mutia Canan | |
dc.date.accessioned | 2014-08-14T14:14:41Z | |
dc.date.available | 2014-08-14T14:14:41Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Gormus U, Timirci Kahraman O, Toptas B, Isbir T, Ciftci C, Berkkan HH, Dalan AB, Karatay MC. Leptin and leptin receptor polymorphisms are related to body mass index in a Turkish population. Turkish Journal of Medical Sciences. 2014; 44(5): 809-13. doi:10.3906/sag-1211-80 | en_US |
dc.identifier.issn | 1300-0144 | |
dc.identifier.uri | journals.tubitak.gov.tr | en_US |
dc.identifier.uri | https://hdl.handle.net/11446/445 | en_US |
dc.description | İstanbul Bilim Üniversitesi, Tıp Fakültesi. | en_US |
dc.description.abstract | Background/aim: Leptin is a hormone that is known to be related to weight gain and obesity. The soluble leptin receptor has been found
in plasma as an important determinant of leptin sensitivity. In this study, our goal was to investigate the association between leptin levels
and leptin receptor polymorphisms in a Turkish population.
Materials and methods: The sample pool of this study consisted of 202 subjects. G2548A variant in the promoter region of the leptin
gene and Q223R polymorphism of the leptin receptor gene were evaluated by using PCR-RFLP. Leptin levels were determined by ELISA.
Results: Leptin levels were significantly higher in subjects with the A allele than in subjects without the A allele. Leptin receptor levels
were lower in subjects with the AA genotype than in those with the AG genotype. There was a higher prevalence of the leptin-2548 AA
genotype among subjects with a BMI ≥ 25 kg/m2 than in those with a BMI < 25 kg/m2.
Conclusion: The leptin-2548A allele might be a predisposing factor for obesity. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TUBİTAK | en_US |
dc.relation.uri | http://mistug.tubitak.gov.tr/bdyim/toc.php?dergi=sag&yilsayi=2014/5 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | leptin | en_US |
dc.subject | leptin receptor | en_US |
dc.subject | obesity | en_US |
dc.title | Leptin and leptin receptor polymorphisms are related to body mass index in a Turkish population | en_US |
dc.type | article | en_US |
dc.relation.journal | Turkish Journal of Medical Sciences | en_US |
dc.department | DBÜ, Tıp Fakültesi | en_US |
dc.identifier.issue | 5 | |
dc.identifier.volume | 44 | |
dc.identifier.startpage | 809 | |
dc.identifier.endpage | 813 | |
dc.contributor.authorID | TR34467 | en_US |
dc.contributor.authorID | TR167477 | en_US |
dc.contributor.authorID | TR167799 | en_US |
dc.contributor.authorID | TR23475 | en_US |
dc.contributor.authorID | TR115014 | en_US |
dc.relation.publicationcategory | Belirsiz | en_US |