MMP2 gene polymorphisms and MMP2 mRNA levels in patients with superficial varices of lower extremities

Abstract

Background: Although superficial varices of the lower extremities are common and with high morbidity, their etiology has not been elucidated yet. Previously, it was thought that venous hypertension was responsible for such cases by causing valvular insufficiency. However, recent findings indicate that the changes in the venous wall structure may be the main initiating factors of this condition. Matrix metalloproteinase enzyme-2 (MMP2) is one of the enzymes known to have a role in remodelling the extracellular matrix, mainly in vascular structures.