Detection of visual and frontoparietal network perfusion deficits in Parkinson's disease dementia
dc.contributor.author | Azamat, S. | |
dc.contributor.author | Betul Arslan, D. | |
dc.contributor.author | Erdogdu, E. | |
dc.contributor.author | Kicik, A. | |
dc.contributor.author | Cengiz, S. | |
dc.contributor.author | Eryürek, K. | |
dc.contributor.author | Tufekcioglu, Z. | |
dc.date.accessioned | 2022-01-29T16:52:25Z | |
dc.date.available | 2022-01-29T16:52:25Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0720048X | |
dc.identifier.uri | https://doi.org/10.1016/j.ejrad.2021.109985 | |
dc.identifier.uri | http://hdl.handle.net/11446/4464 | |
dc.description.abstract | Mild cognitive impairment of Parkinson's disease (PD) may be an early manifestation that may progressively worsen to dementia. Cognitive decline has been associated with changes in the brain perfusion pattern. This study aimed to evaluate cerebral blood flow (CBF) deficits specific to different stages of cognitive decline. Seventeen patients with cognitively normal PD (PD-CN), 18 patients with PD with mild cognitive impairment (PD-MCI), and 16 patients with PD with dementia (PDD) were included in this study. The participants were scanned using a 3 T Philips MRI scanner. Arterial spin labelling magnetic resonance (ASL-MR) images were acquired, followed by calculation of the CBF maps, and registration onto the MNI152 brain atlas. A whole-brain voxel-based CBF comparison was performed among the patient groups using age as a covariate. The mean age of patients with PDD was significantly higher than that of patients with PD-MCI (P = 0.015) and PD-CN (P = 0.001). The CBF values of the three groups were significantly different in the left cuneus of the visual network (VN), left inferior frontal gyrus of the frontoparietal network (FPN), and left dorsomedial nucleus of the thalamus. PDD had lower perfusion values than PD-MCI group in the same regions detected in the main group analysis. Additionally, comparison of PDD with PD-CN and non-demented groups revealed that the perfusion reduction extended into the bilateral cuneus of the VN, bilateral thalami, and left inferior frontal gyrus of the FPN. PDD could be separated from PD-MCI and PD-CN stages with CBF deficits in non-dopaminergically mediated posterior and dopaminergically mediated frontal networks. © 2021 | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Ireland Ltd | en_US |
dc.identifier.doi | 10.1016/j.ejrad.2021.109985 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Arterial Spin Labelling Magnetic Resonance Imaging (ASL-MRI); Mild cognitive impairment with Parkinson's disease (PD-MCI); Parkinson Disease (PD); Parkinson Disease dementia (PDD); Resting state functional MRI (rs-fMRI) networks | en_US |
dc.subject | adult | en_US |
dc.subject | age | en_US |
dc.subject | aged | en_US |
dc.subject | arterial spin labeling | en_US |
dc.subject | Article | en_US |
dc.subject | brain blood flow | en_US |
dc.subject | brain perfusion | en_US |
dc.subject | clinical article | en_US |
dc.subject | controlled study | en_US |
dc.subject | cuneus | en_US |
dc.subject | dementia | en_US |
dc.subject | female | en_US |
dc.subject | frontoparietal network | en_US |
dc.subject | functional magnetic resonance imaging | en_US |
dc.subject | functional neuroimaging | en_US |
dc.subject | human | en_US |
dc.subject | inferior frontal gyrus | en_US |
dc.subject | left hemisphere | en_US |
dc.subject | male | en_US |
dc.subject | mild cognitive impairment | en_US |
dc.subject | Parkinson disease | en_US |
dc.subject | thalamus dorsomedial nucleus | en_US |
dc.subject | visual network | en_US |
dc.subject | brain | en_US |
dc.subject | cognitive defect | en_US |
dc.subject | complication | en_US |
dc.subject | diagnostic imaging | en_US |
dc.subject | neuropsychological test | en_US |
dc.subject | nuclear magnetic resonance imaging | en_US |
dc.subject | perfusion | en_US |
dc.subject | Brain | en_US |
dc.subject | Cognitive Dysfunction | en_US |
dc.subject | Dementia | en_US |
dc.subject | Humans | en_US |
dc.subject | Magnetic Resonance Imaging | en_US |
dc.subject | Neuropsychological Tests | en_US |
dc.subject | Parkinson Disease | en_US |
dc.subject | Perfusion | en_US |
dc.title | Detection of visual and frontoparietal network perfusion deficits in Parkinson's disease dementia | en_US |
dc.type | article | en_US |
dc.relation.journal | European Journal of Radiology | en_US |
dc.department | DBÜ | en_US |
dc.identifier.volume | 144 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | Azamat, S., Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey, Başakşehir Çam and Sakura City Hospital, Istanbul, Turkey; Betul Arslan, D., Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey; Erdogdu, E., Neuroimaging Unit Hulusi Behcet Life Sciences Research Center, Istanbul University, Istanbul, Turkey, Department of Psychology, Faculty of Arts and Sciences, Isik University, Istanbul, Turkey; Kicik, A., Neuroimaging Unit Hulusi Behcet Life Sciences Research Center, Istanbul University, Istanbul, Turkey, Department of Physiology, Faculty of Medicine, Demircioglu Bilim University, Istanbul, Turkey; Cengiz, S., Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey; Eryürek, K., Neuroimaging Unit Hulusi Behcet Life Sciences Research Center, Istanbul University, Istanbul, Turkey, Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey; Tufekcioglu, Z., Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey; Bilgic, B., Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey; Hanagasi, H., Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey; Demiralp, T., Neuroimaging Unit Hulusi Behcet Life Sciences Research Center, Istanbul University, Istanbul, Turkey, Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey; Gurvit, H., Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey; Ozturk-Isik, E., Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey | en_US |
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