dc.contributor.author | Özdilli, K. | |
dc.contributor.author | Savran O?uz, F. | |
dc.contributor.author | Anak, S. | |
dc.contributor.author | Ö?ret, Y. | |
dc.contributor.author | Çiftçi, H.Ş. | |
dc.contributor.author | O?uz, R. | |
dc.contributor.author | Carin, M. | |
dc.date.accessioned | 2022-01-29T16:52:27Z | |
dc.date.available | 2022-01-29T16:52:27Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 13059319 | |
dc.identifier.uri | https://doi.org/10.4274/BMJ.galenos.2021.41636 | |
dc.identifier.uri | http://hdl.handle.net/11446/4475 | |
dc.description.abstract | Objective: Hematopoietic stem cell transplantation (HSCT) is an important therapy for hematological diseases. One of the most significant complications of HSCT is graft versus host disease (GVHD), and major histocompatibility complex (MHC) is well known to affect GVHD and graft rejection. This study aimed to examine the effect of human leukocyte antigens (HLA) on the incidence of GVHD development in patients with leukemia. Methods: The association between HLA and GVHD formation was evaluated in 57 patients with HSCT with HLA-identical sibling donors, of whom 37 were boys and 20 were girls with a mean age of 10.11 years. All patients were diagnosed with leukemia; acute myeloid leukemia (n=33), acute lymphoblastic leukemia (n=15), and chronic myeloid leukemia (n=9). Transplantation pairs were worked for HLA-A, -B, -C, and -DRB1 alleles. Class I HLA antigens were investigated using Terasaki microlymphocytotoxicity, whereas class II HLA alleles with polymerase chain reaction - sequence-specific amplification method. Results: The frequency of developing GVHD in patients with HSCT was found to be 17.5% (n=10). HLA-DRB1?04 allelic frequency [p=0.024, odds ratio (OR): 4.87] was found to be higher in patients who developed GVHD. However, the HLA-DRB1?11 allelic frequency (p=0.031, OR: 0.12) was lower in patients who developed GVHD compared to patients who did not develop GVHD. Furthermore, HLA-B38 (p=0.002) and HLA-B41 (p=0.002) antigens were found only in patients who developed GVHD. The frequencies of the HLA-A26 allele (p=0.12) and the HLADRB1?11 allele (p=0.037, OR: 4.0) were higher in patients with relapse after HSCT; however, the frequencies of the HLA-A2 allele (p=0.033, OR: 0.19) was lower in patients who relapsed after HSCT. Conclusion: This study assessed the relationship of HLA class with GVHD, relapse, and survival in children after HSCT in pediatric patients with leukemia. © 2021 Galenos Publishing House. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Galenos Publishing House | en_US |
dc.identifier.doi | 10.4274/BMJ.galenos.2021.41636 | |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | GVHD; HLA; HSCT; Leukemia | en_US |
dc.subject | busulfan | en_US |
dc.subject | cyclophosphamide | en_US |
dc.subject | etoposide | en_US |
dc.subject | HLA A antigen | en_US |
dc.subject | HLA antigen | en_US |
dc.subject | HLA B antigen | en_US |
dc.subject | HLA B38 antigen | en_US |
dc.subject | HLA C antigen | en_US |
dc.subject | HLA DRB1 antigen | en_US |
dc.subject | acute lymphoblastic leukemia | en_US |
dc.subject | acute myeloid leukemia | en_US |
dc.subject | allele | en_US |
dc.subject | Article | en_US |
dc.subject | cancer survival | en_US |
dc.subject | cancer transplantation | en_US |
dc.subject | child | en_US |
dc.subject | chronic myeloid leukemia | en_US |
dc.subject | controlled study | en_US |
dc.subject | disease association | en_US |
dc.subject | female | en_US |
dc.subject | gene frequency | en_US |
dc.subject | graft survival | en_US |
dc.subject | graft versus host reaction | en_US |
dc.subject | hematopoietic stem cell transplantation | en_US |
dc.subject | human | en_US |
dc.subject | human cell | en_US |
dc.subject | human tissue | en_US |
dc.subject | lymphocytotoxicity | en_US |
dc.subject | major clinical study | en_US |
dc.subject | male | en_US |
dc.subject | pediatric patient | en_US |
dc.subject | polymerase chain reaction | en_US |
dc.subject | school child | en_US |
dc.subject | sibling donor | en_US |
dc.subject | survival rate | en_US |
dc.title | The Influence of Human Leukocyte Antigens in Graft Versus Host Disease and Survival After Hematopoiet ic Stem Cell Transplantation in Pediatric Patients with Leukemia | en_US |
dc.type | article | en_US |
dc.relation.journal | Medical Journal of Bakirkoy | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.volume | 17 | en_US |
dc.identifier.startpage | 280 | en_US |
dc.identifier.endpage | 285 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | Özdilli, K., Medipol University, Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey, Istanbul University, Istanbul Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey; Savran O?uz, F., Istanbul University, Istanbul Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey; Anak, S., Medipol University, Faculty of Medicine, Department of Pediatric Hematology, Istanbul, Turkey; Ö?ret, Y., Istanbul University, Istanbul Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey; Çiftçi, H.Ş., Istanbul University, Istanbul Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey; O?uz, R., Istanbul Demiro?lu Bilim University, Gayrettepe Florence Nightingale Hospital, Tissue Typing and Immunogenetic Laboratory, Istanbul, Turkey; Carin, M., Istinye University, Tissue Typing and Immunogenetic Laboratory, Istanbul, Turkey | en_US |