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Characteristics and outcomes of carbapenemase harbouring carbapenem-resistant Klebsiella spp. bloodstream infections: a multicentre prospective cohort study in an OXA-48 endemic setting

dc.contributor.authorIsler, Burcu
dc.contributor.authorOzer, Berna
dc.contributor.authorCinar, Gule
dc.contributor.authorAslan, Abdullah Tarik
dc.contributor.authorVatansever, Cansel
dc.contributor.authorFalconer, Caitlin
dc.contributor.authorErgonul, Onder
dc.date.accessioned2022-11-04T19:55:26Z
dc.date.available2022-11-04T19:55:26Z
dc.date.issued2022
dc.identifier.issn0934-9723
dc.identifier.issn1435-4373
dc.identifier.urihttps://doi.org/10.1007/s10096-022-04425-4
dc.identifier.urihttp://hdl.handle.net/11446/4524
dc.description.abstractA prospective, multicentre observational cohort study of carbapenem-resistant Klebsiella spp. (CRK) bloodstream infections was conducted in Turkey from June 2018 to June 2019. One hundred eighty-seven patients were recruited. Single OXA-48-like carbapenemases predominated (75%), followed by OXA-48-like/NDM coproducers (16%). OXA-232 constituted 31% of all OXA-48-like carbapenemases and was mainly carried on ST2096. Thirty-day mortality was 44% overall and 51% for ST2096. In the multivariate cox regression analysis, SOFA score and immunosuppression were significant predictors of 30-day mortality and ST2096 had a non-significant effect. All OXA-48-like producers remained susceptible to ceftazidime-avibactam.en_US
dc.description.sponsorshipPfizer Global Medical Grants [56644459]en_US
dc.description.sponsorshipThis work was supported by Pfizer Global Medical Grants (grant number 56644459).en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal of Clinical Microbiology & Infectious Diseasesen_US
dc.identifier.doi10.1007/s10096-022-04425-4en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOXA-48en_US
dc.subjectOXA-232en_US
dc.subjectST2096en_US
dc.subjectKlebsiella pneumoniaeen_US
dc.subjectCeftazidime-avibactamen_US
dc.subjectPneumoniaeen_US
dc.subjectOxa-232en_US
dc.subjectEnterobacteralesen_US
dc.subjectCoproductionen_US
dc.subjectSpreaden_US
dc.subjectNdm-1en_US
dc.titleCharacteristics and outcomes of carbapenemase harbouring carbapenem-resistant Klebsiella spp. bloodstream infections: a multicentre prospective cohort study in an OXA-48 endemic settingen_US
dc.typearticleen_US
dc.identifier.issue5en_US
dc.identifier.volume41en_US
dc.identifier.startpage841en_US
dc.identifier.endpage847en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-temp[Isler, Burcu; Falconer, Caitlin; Chatfield, Mark D.; Forde, Brian; Paterson, David L.] Univ Queensland, Ctr Clin Res, Brisbane, Qld, Australia; [Ozer, Berna; Vatansever, Cansel; Dogan, Ozlem; Can, Fusun] Koc Univ, Sch Med, Clin Microbiol, Istanbul, Turkey; [Cinar, Gule; Azap, Alpay] Ankara Univ, Infect Dis & Clin Microbiol, Sch Med, Ankara, Turkey; [Aslan, Abdullah Tarik; Akova, Murat] Hacettepe Univ, Infect Dis & Clin Microbiol, Sch Med, Ankara, Turkey; [Dolapci, Istar] Ankara Univ, Clin Microbiol, Sch Med, Ankara, Turkey; [Simsek, Funda] Univ Hlth Sci, Minist Hlth, Infect Dis & Clin Microbiol, Prof Dr Cemil Tascioglu City Hosp, Istanbul, Turkey; [Tulek, Necla] Atilim Univ, Fac Med, Infect Dis & Clin Microbiol, Ankara, Turkey; [Demirkaya, Hamiyet; Azap, Ozlem] Baskent Univ, Ankara Hosp, Infect Dis & Clin Microbiol, Ankara, Turkey; [Menekse, Sirin] Kosuyolu Kartal Heart Training & Res Hosp, Infect Dis, Istanbul, Turkey; [Akalin, Halis] Uluda Univ, Infect Dis & Clin Microbiol, Sch Med, Bursa, Turkey; [Balkan, Ilker Inanc; Saltoglu, Nese] Istanbul Univ Cerrahpasa, Sch Med, Infect Dis & Clin Microbiol, Istanbul, Turkey; [Aydin, Mehtap] Univ Hlth Sci, Umraniye Training & Res Hosp, Infect Dis & Clin Microbiol, Istanbul, Turkey; [Tigen, Elif Tukenmez] Marmara Univ, Pendik Training & Res Hosp, Infect Dis & Clin Microbiol, Istanbul, Tuen_US
dc.authoridDOGAN, OZLEM/0000-0002-6505-4582
dc.authoridErgonul, Onder/0000-0003-1935-9235
dc.authoridCinar, Gule/0000-0002-7635-8848
dc.authoridKeske, Siran/0000-0003-3823-4454
dc.authoridGönen, Mehmet/0000-0002-2483-075X
dc.authoridFalconer, Caitlin/0000-0002-0476-7714
dc.identifier.pmid35301623en_US
dc.identifier.scopus2-s2.0-85126797654en_US
dc.identifier.wosWOS:000770200000001en_US
dc.authorwosidAkalin, Halis/AAU-8952-2020
dc.authorwosidDOGAN, OZLEM/M-4757-2017
dc.authorwosidCinar, Gule/ABA-2413-2020
dc.authorwosidErgonul, Onder/GPK-0581-2022
dc.authorwosidKeske, Siran/AAG-3483-2019
dc.authorwosidGönen, Mehmet/O-7322-2015
dc.authorscopusid57206274628
dc.authorscopusid57210635288
dc.authorscopusid57210793543
dc.authorscopusid57208546633
dc.authorscopusid57214119170
dc.authorscopusid57221350758
dc.authorscopusid6602421323


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