dc.contributor.author | Cengiz, Sevim | |
dc.contributor.author | Arslan, Dilek Betul | |
dc.contributor.author | Kicik, Ani | |
dc.contributor.author | Erdogdu, Emel | |
dc.contributor.author | Yildirim, Muhammed | |
dc.contributor.author | Hatay, Gokce Hale | |
dc.contributor.author | Ozturk-Isik, Esin | |
dc.date.accessioned | 2022-11-04T19:55:26Z | |
dc.date.available | 2022-11-04T19:55:26Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 1352-8661 | |
dc.identifier.uri | https://doi.org/10.1007/s10334-022-01030-6 | |
dc.identifier.uri | http://hdl.handle.net/11446/4526 | |
dc.description.abstract | Objective To investigate metabolic changes of mild cognitive impairment in Parkinson's disease (PD-MCI) using proton magnetic resonance spectroscopic imaging (H-1-MRSI). Methods Sixteen healthy controls (HC), 26 cognitively normal Parkinson's disease (PD-CN) patients, and 34 PD-MCI patients were scanned in this prospective study. Neuropsychological tests were performed, and three-dimensional H-1-MRSI was obtained at 3 T. Metabolic parameters and neuropsychological test scores were compared between PD-MCI, PD-CN, and HC. The correlations between neuropsychological test scores and metabolic intensities were also assessed. Supervised machine learning algorithms were applied to classify HC, PD-CN, and PD-MCI groups based on metabolite levels. Results PD-MCI had a lower corrected total N-acetylaspartate over total creatine ratio (tNAA/tCr) in the right precentral gyrus, corresponding to the sensorimotor network (p = 0.01), and a lower tNAA over myoinositol ratio (tNAA/mI) at a part of the default mode network, corresponding to the retrosplenial cortex (p = 0.04) than PD-CN. The HC and PD-MCI patients were classified with an accuracy of 86.4% (sensitivity = 72.7% and specificity = 81.8%) using bagged trees. Conclusion H-1-MRSI revealed metabolic changes in the default mode, ventral attention/salience, and sensorimotor networks of PD-MCI patients, which could be summarized mainly as 'posterior cortical metabolic changes' related with cognitive dysfunction. | en_US |
dc.description.sponsorship | Scientific and Technological Research Council of Turkey (TUBITAK) 1001 Grant [115S219]; Istanbul University [1567/42362] | en_US |
dc.description.sponsorship | This study was funded by The Scientific and Technological Research Council of Turkey (TUBITAK) 1001 Grant #115S219 and Istanbul University Scientific Research Projects Unit project #1567/42362. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.relation.ispartof | Magnetic Resonance Materials In Physics Biology and Medicine | en_US |
dc.identifier.doi | 10.1007/s10334-022-01030-6 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Magnetic resonance spectroscopy | en_US |
dc.subject | Parkinson's disease | en_US |
dc.subject | Cognitive dysfunction | en_US |
dc.subject | Machine learning | en_US |
dc.subject | Posterior Cingulate Cortex | en_US |
dc.subject | Nondemented Patients | en_US |
dc.subject | Diagnostic-Criteria | en_US |
dc.subject | Dementia | en_US |
dc.subject | Movement | en_US |
dc.subject | Connectivity | en_US |
dc.subject | Networks | en_US |
dc.subject | Hypoperfusion | en_US |
dc.subject | Associations | en_US |
dc.subject | Robust | en_US |
dc.title | Identification of metabolic correlates of mild cognitive impairment in Parkinson's disease using magnetic resonance spectroscopic imaging and machine learning | en_US |
dc.type | article | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Cengiz, Sevim; Arslan, Dilek Betul; Yildirim, Muhammed; Hatay, Gokce Hale; Ulug, Aziz Mufit; Ozturk-Isik, Esin] Bogazici Univ, Inst Biomed Engn, TR-34684 Istanbul, Turkey; [Kicik, Ani; Erdogdu, Emel; Demiralp, Tamer] Istanbul Univ, Hulusi Behcet Life Sci Res Ctr, Neuroimaging Unit, Istanbul, Turkey; [Kicik, Ani] Demiroglu Bilim Univ, Fac Med, Dept Physiol, Istanbul, Turkey; [Erdogdu, Emel] Isik Univ, Fac Econ & Adm Sci, Dept Psychol, Istanbul, Turkey; [Tufekcioglu, Zeynep; Bilgic, Basar; Hanagasi, Hasmet; Gurvit, Hakan] Istanbul Univ, Istanbul Fac Med, Dept Neurol, Behav Neurol & Movement Disorders Unit, Istanbul, Turkey; [Tufekcioglu, Zeynep] Istanbul Aydin Univ, Fac Med, Dept Neurol, Istanbul, Turkey; [Ulug, Aziz Mufit] CorTechs Labs, San Diego, CA USA; [Demiralp, Tamer] Istanbul Univ, Istanbul Fac Med, Dept Physiol, Istanbul, Turkey | en_US |
dc.authorid | Arslan, Dilek Betul/0000-0002-1124-3695 | |
dc.authorid | Cengiz, Sevim/0000-0002-1332-3007 | |
dc.identifier.pmid | 35867235 | en_US |
dc.identifier.scopus | 2-s2.0-85134713185 | en_US |
dc.identifier.wos | WOS:000828927500002 | en_US |
dc.authorscopusid | 57194830524 | |
dc.authorscopusid | 55948705300 | |
dc.authorscopusid | 57210410250 | |
dc.authorscopusid | 57204623742 | |
dc.authorscopusid | 56016941200 | |
dc.authorscopusid | 56529727300 | |
dc.authorscopusid | 56538592000 | |