Evaluation of oxidative stress markers in type-2 diabetic rat kidney with treated Δ9-THC

Abstract

Oxidative stress plays a major role in the pathogenesis of diabetes mellitus. Impaired redox homeostasis can lead to the damage of macromolecules and insulin resistance. Thus, oxidative stress promotes the development of complication of diabetes [1-4]. It is suggested that diabetes induce oxidative stress in kidney [5]. Δ9-tetrahydrocannabinol (Δ9-THC) has been shown to interfere with both the function of insulin and its release. The activation of cannabinoid receptors stimulates insulin secretion to maintain glucose homeostasis [6-7]. The current study, we aimed to evaluate effects of Δ9-THC on oxidative stress markers with respect to antioxidant status in kidney tissue of streptozotosin + nicotinamid induced type 2 diabetic rats.