dc.contributor.author | Pala, Emel Ebru | |
dc.contributor.author | Pala, Halil Gursoy | |
dc.contributor.author | Ekmekci, Sumeyye | |
dc.contributor.author | Erbas, Oytun | |
dc.date.accessioned | 2022-11-04T19:55:34Z | |
dc.date.available | 2022-11-04T19:55:34Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 0104-4230 | |
dc.identifier.issn | 1806-9282 | |
dc.identifier.uri | https://doi.org/10.1590/1806-9282.20220032 | |
dc.identifier.uri | http://hdl.handle.net/11446/4565 | |
dc.description.abstract | OBJECTIVE: We aimed to determine whether vitamin C has a protective effect on cisplatin-induced neuropathy in rats.METHODS: In total, 24 rats were included in the study of which 8 rats (no drug administered) were categorized as the control group. The remaining 16 rats were given a total dose of 20 mg/kg cisplatin to induce neuropathy. These drug-administered rats (16 rats) were randomly divided into two groups, namely, group-1 (n=8): cisplatin+saline and group-2 (n=8): cisplatin+vitamin C (500 mg/kg/day). All rats were tested for motor function and electromyographic activity 3 days after cisplatin. Motor performance was evaluated by an inclined-plane test. Compound muscle action potential was evaluated. Plasma malondialdehyde, glutathione, tumor necrosis factor-alpha, interleukin 6, and sciatic nerve HSP 70 levels were measured. Axon diameter and nerve growth factor expression levels were analyzed.RESULTS: Plasma malondialdehyde, tumor necrosis factor-alpha, and interleukin 6 levels were higher in the cisplatin+saline group than control group (p<0.001). But vitamin C significantly reduced malondialdehyde and inflammatory cytokine levels when compared with the cisplatin+saline group (p<0.001). Glutathione levels were lower in both cisplatin+saline and cisplatin+vitamin C groups than control group, but vitamin C significantly ameliorated the glutathione levels (p<0.05). Sciatic heat shock protein-70 levels were significantly higher in the cisplatin+vitamin C group than cisplatin+saline group. Compound muscle action potential amplitude and inclined plane test scores were significantly improved in the vitamin C group (p<0.05). Axon diameter and nerve growth factor expression ameliorated with vitamin C (p<0.05).CONCLUSIONS: We demonstrated the ameliorated effects of vitamin C on cisplatin-induced neuropathy through increased heat shock protein-70, nerve growth factor levels, and reduced inflammatory and oxidant effects. The results are promising to improve the neurotoxic effects of cisplatin in cancer patients. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Assoc Medica Brasileira | en_US |
dc.relation.ispartof | Revista Da Associacao Medica Brasileira | en_US |
dc.identifier.doi | 10.1590/1806-9282.20220032 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Cisplatin | en_US |
dc.subject | Drug related side effects | en_US |
dc.subject | adverse reactions | en_US |
dc.subject | Ascorbic acid | en_US |
dc.subject | Heat shock proteins | en_US |
dc.subject | Nerve Growth-Factor | en_US |
dc.subject | Oxidative Stress | en_US |
dc.subject | Neurotoxicity | en_US |
dc.subject | Nephrotoxicity | en_US |
dc.subject | Combination | en_US |
dc.title | Vitamin C (Ascorbic acid) protects from neuropathy caused by cisplatin, through enhanced heat shock protein-70 and reduced oxidant effect | en_US |
dc.type | article | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.volume | 68 | en_US |
dc.identifier.startpage | 1017 | en_US |
dc.identifier.endpage | 1022 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Pala, Emel Ebru; Ekmekci, Sumeyye] Univ Hlth Sci, Tepecik Hlth Practice & Res Ctr, Dept Pathol Izmir, Izmir, Turkey; [Pala, Halil Gursoy] Univ Hlth Sci, Tepecik Hlth Practice & Res Ctr, Dept Obstet & Gynecol Izmir, Izmir, Turkey; [Erbas, Oytun] Bilim Univ, Dept Physiol Istanbul, Med Fac, Istanbul, Turkey | en_US |
dc.identifier.pmid | 36134830 | en_US |
dc.identifier.scopus | 2-s2.0-85138259481 | en_US |
dc.identifier.wos | WOS:000865466400011 | en_US |
dc.authorscopusid | 25923492400 | |
dc.authorscopusid | 36483325500 | |
dc.authorscopusid | 55375424200 | |
dc.authorscopusid | 55469991100 | |