dc.contributor.author | Ozdilli, Kursat | |
dc.contributor.author | Ogret, Yeliz Duvarci | |
dc.contributor.author | Oguz, Rustu | |
dc.contributor.author | Issever, Halim | |
dc.contributor.author | Yokes, Mehmet Baki | |
dc.contributor.author | Ciftci, Hayriye Senturk | |
dc.contributor.author | Oguz, Fatma Savran | |
dc.date.accessioned | 2022-11-04T19:55:41Z | |
dc.date.available | 2022-11-04T19:55:41Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 1305-2381 | |
dc.identifier.uri | http://hdl.handle.net/11446/4600 | |
dc.description.abstract | Objective: Short:tandem repeats (STRs) are short sequences of nucleotides that are repeated and distributed all over the genome. These polymorphisms enable investigation of the forensic, ancestral lineage and evolutionary studies in human population. Owing to the historical migration and ethnic groups, it is very valuable to evaluate genetic distances in Turkey. The aim of the present study is to examine the STR data of Istanbul and compare the genetic distances and allele frequency with the previously published data of 27 countries from Europe, Asia, America, Africa and Middle East. Material and Method: Peripheral blood samples were obtained from 400 healthy individuals. DNA samples were amplified using a commercial kit. Multiplex STR-PCR (Applied Biosystems, Foster City, CA, USA) was used and the amplicons were evaluated on an ABI 3130 Genetic Analyzer. Results: Among all loci, D21S11 and D18S51 were the most polymorphic loci. The power of discrimination (PD) ranged from 0.8329 (TPDX) to 0.9722 (D18S51). The combined PD and probability of exclusion (PE) were found to he >0.99999999 and 0.99999671. respectively. Conclusion: In this study, six STR markers were selected to compare the genetic distances and allele frequency of the present results with the results of twenty-seven studies which were published previously. This study indicates that the population in Turkey is an intermediate between Europe, Middle East and Central Asia. | en_US |
dc.description.sponsorship | related to the ethnic origins of the volunteers could not be obtained. This is a limitation of the study. The median age in the subject group was 46.3 (min.21, max.91 y) years. All subjects volunteered to participate in the study and were informed about the study. Written informed consent was obtained from all subjects. The procedures were carefully explained to all volunteers. The study was performed according to the amended Declaration of Helsinki and approved by the Clinical Research Ethics Committee of Haliç University (17.03.2011, 2011-03/02). This study was supported by the Scientific Research Fund of Haliç University. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Nobel Ilac | en_US |
dc.relation.ispartof | Nobel Medicus | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Human genetics | en_US |
dc.subject | polymorphism | en_US |
dc.subject | population genetics | en_US |
dc.subject | short tandem repeat | en_US |
dc.subject | Ampflstr Identifiler Loci | en_US |
dc.subject | Tandem Repeat Loci | en_US |
dc.subject | Allele Frequencies | en_US |
dc.subject | Ethnic Populations | en_US |
dc.subject | Multiplex | en_US |
dc.title | GENETIC POLYMORPHISMS IN 15 STR LOCI IN THE TURKISH POPULATION LIVING IN ISTANBUL PROVINCE | en_US |
dc.title.alternative | İSTANBUL’DA YAŞAYAN TÜRK NÜFUSUNDA 15 STR LOKUSUNDA GENETİK POLİMORFİZMLER | en_US |
dc.type | article | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.volume | 18 | en_US |
dc.identifier.startpage | 54 | en_US |
dc.identifier.endpage | 61 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Ozdilli, Kursat] Medipol Univ, Dept Med Biol, Istanbul, Turkey; [Ozdilli, Kursat] Halic Univ, Sch Nursing, Istanbul, Turkey; [Ogret, Yeliz Duvarci; Ciftci, Hayriye Senturk; Sel, Figen Abatay; Kivanc, Demet; Cinar, Cigdem Kekik; Pehlivan, Sacide; Oguz, Fatma Savran] Istanbul Univ, Istanbul Fac Med, Dept Med Biol, Istanbul, Turkey; [Oguz, Rustu] Istanbul Bilim Univ, Dept Med Biol, Gayrettepe Florence Nightingale Hosp, Tissue Typing & Immunogenet Lab, Istanbul, Turkey; [Issever, Halim] Istanbul Univ, Istanbul Fac Med, Dept Publ Hlth, Istanbul, Turkey; [Yokes, Mehmet Baki] Halic Univ, Fac Arts & Sci, Dept Mol Biol, Istanbul, Turkey; [Yokes, Mehmet Baki] AMBRD Doga Bilimleri Istanbul, Istanbul, Turkey | en_US |
dc.identifier.scopus | 2-s2.0-85130045366 | en_US |
dc.identifier.wos | WOS:000798416700006 | en_US |
dc.authorwosid | Ozdilli, Kursat/S-2412-2016 | |
dc.authorscopusid | 12774041000 | |
dc.authorscopusid | 56196459300 | |
dc.authorscopusid | 57404189300 | |
dc.authorscopusid | 55834600600 | |
dc.authorscopusid | 18042811200 | |
dc.authorscopusid | 6701904053 | |
dc.authorscopusid | 57687890700 | |