dc.contributor.author | Kar, F. | |
dc.contributor.author | Hacıoğlu, C. | |
dc.contributor.author | Göncü, Y. | |
dc.contributor.author | Söğüt, İ. | |
dc.contributor.author | Şenturk, H. | |
dc.contributor.author | Burukoğlu Dönmez, D. | |
dc.contributor.author | Ay, N. | |
dc.date.accessioned | 2022-11-04T19:55:42Z | |
dc.date.available | 2022-11-04T19:55:42Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1040-7278 | |
dc.identifier.uri | https://doi.org/10.1007/s10876-020-01811-w | |
dc.identifier.uri | http://hdl.handle.net/11446/4607 | |
dc.description.abstract | The aim of our study is to investigate the dose-dependent biological system effect of hexagonal boron nitride (hBN) nanoparticles, which is directly produced nanoscale, in vivo. Wistar albino rats (n = 80) weighing 200–250 g were divided into eight groups (n = 10). The acute effects of hBN NPs (i.v) on the rats were investigated by measuring the biochemical, hematological parameters and oxidant-antioxidant status. The results show that no significant change was observed in the hematological and biochemical parameters when the control group and other low dose groups were compared, except for the 1600 and 3200 µg/kg b.w. dose groups. Histological detection indicated that 1600 and 3200 µg/kg hBN NPs treatment could induce significant damage in the liver, kidney, heart, spleen and pancreas. With the findings obtained, it can be seen that hBN NPs cannot be evaluated independently of particle morphology, and that the hBN NPs used in this study may be suitable for biomedical applications where low doses between 50 and 800 µg/kg are not toxic. © 2020, Springer Science+Business Media, LLC, part of Springer Nature. | en_US |
dc.description.sponsorship | 19ADP163; Eskişehir Teknik Üniversitesi, ESTÜ | en_US |
dc.description.sponsorship | This study was supported by Eskişehir Technical University Scientific Research Projects Commission. (Project No: 19ADP163). The authors would like to thank BORTEK Boron Technologies and Mechatronic Inc. for their material support and Dr. Umut SAVACI for his help to use Transmission Electron Microscopy (TEM) (Eskisehir Technical University, Turkey). | en_US |
dc.description.sponsorship | This study was supported by Eskişehir Technical University Scientific Research Projects Commission. (Project No: 19ADP163). The authors would like to thank BORTEK Boron Technologies and Mechatronic Inc. for their material support and Dr. Umut SAVACI for his help to use Transmission Electron Microscopy (TEM) (Eskisehir Technical University, Turkey). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.relation.ispartof | Journal of Cluster Science | en_US |
dc.identifier.doi | 10.1007/s10876-020-01811-w | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Cytotoxicity | en_US |
dc.subject | Hexagonal boron nitride | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Rat | en_US |
dc.subject | Serum | en_US |
dc.title | In Vivo Assessment of the Effect of Hexagonal Boron Nitride Nanoparticles on Biochemical, Histopathological, Oxidant and Antioxidant Status | en_US |
dc.type | article | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.volume | 32 | en_US |
dc.identifier.startpage | 517 | en_US |
dc.identifier.endpage | 529 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | Kar, F., Department of Medical Biochemistry, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey; Hacıoğlu, C., Department of Medical Biochemistry, Faculty of Medicine, Duzce University, Duzce, Turkey; Göncü, Y., Department of Biomedical Engineering, Faculty of Engineering and Architecture, Osmangazi University, Eskisehir, Turkey, Boron Technologies and Mechatronics Inc, Eskisehir, Turkey; Söğüt, İ., Department of Medical Biochemistry, Faculty of Medicine, Demiroglu Bilim University, İstanbul, Turkey; Şenturk, H., Department of Biology, Faculty of Arts and Sciences, Eskisehir Osmangazi University, Eskisehir, Turkey; Burukoğlu Dönmez, D., Department of Histology and Embryology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey; Kanbak, G., Department of Medical Biochemistry, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey; Ay, N., Boron Technologies and Mechatronics Inc, Eskisehir, Turkey, Department of Materials Science and Engineering, Eskisehir Technical University, Eskisehir, Turkey | en_US |
dc.identifier.scopus | 2-s2.0-85085019778 | en_US |
dc.authorscopusid | 57208669078 | |
dc.authorscopusid | 57208671422 | |
dc.authorscopusid | 54387957200 | |
dc.authorscopusid | 36615712900 | |
dc.authorscopusid | 35320276300 | |
dc.authorscopusid | 57008255100 | |
dc.authorscopusid | 6603920397 | |