dc.contributor.author | Yazici, Z.M.C. | |
dc.contributor.author | Bilge, B. | |
dc.contributor.author | Bolkent, S. | |
dc.date.accessioned | 2022-11-04T19:55:42Z | |
dc.date.available | 2022-11-04T19:55:42Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 0301-4851 | |
dc.identifier.uri | https://doi.org/10.1007/s11033-022-07996-9 | |
dc.identifier.uri | http://hdl.handle.net/11446/4608 | |
dc.description.abstract | Background: Hyperinsulinemia (HI) means that the amount of insulin in the blood is higher than normal and is often associated with type 2 diabetes. It is known that delta-9-tetrahydrocannabinol (THC) obtained from a medicinal plant, Cannabis sativa, has therapeutic effects on many diseases. Objective: This study aimed to investigate the effects of THC on inflammatory and oxidant status in rat pancreas with HI. Methods: Rats were divided into groups; Control, HI, THC and HI + THC. Each group consists of 8 animals. HI and HI + THC groups were given 10% fructose in the drinking water for 12 weeks. In the last four weeks of the experiment, 1.5 mg kg−1 THC was injected intraperitoneally daily into THC and HI + THC groups. The expression of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and nuclear factor-kappa B (NF-κB) were detected. JNK/SAPK and Grap2/p38 levels, total antioxidant and oxidant capacities (TAC and TOC) were analyzed in the pancreas. Results: Levels of IL-6, NF-κβ, and TNF-α mRNA expression were higher in the pancreas with HI than in the control (p < 0.001 for all). THC treatment reduced the expression of IL-6, NF-κβ, and TNF-α mRNAs in the HI + THC group compared to the HI group (p < 0.001 for all). TOC increased in the HI group compared to the control group (p < 0.001). However, THC treatment reduced TOC levels in the HI + THC group compared to the HI group (p < 0.001). Conclusion: According to the results, the THC treatment may regulate inflammation and TOC in rats with hyperinsulinemia. Thus, we can say that THC may have anti-inflammatory and antioxidant potential in metabolic disorders. © 2022, The Author(s), under exclusive licence to Springer Nature B.V. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer Science and Business Media B.V. | en_US |
dc.relation.ispartof | Molecular Biology Reports | en_US |
dc.identifier.doi | 10.1007/s11033-022-07996-9 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Immunohistochemistry | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Oxidative damage | en_US |
dc.subject | Pancreas | en_US |
dc.subject | THC | en_US |
dc.title | Anti-inflammatory potential of delta-9-tetrahydrocannabinol in hyperinsulinemia: an experimental study | en_US |
dc.type | article | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | Yazici, Z.M.C., Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Demiroglu Bilim University, Istanbul, Turkey; Bilge, B., Department of Medical Biology, Faculty of Cerrahpasa Medicine, Istanbul University-Cerrahpasa, Istanbul, Cerrahpasa, 34098, Turkey; Bolkent, S., Department of Medical Biology, Faculty of Cerrahpasa Medicine, Istanbul University-Cerrahpasa, Istanbul, Cerrahpasa, 34098, Turkey | en_US |
dc.identifier.pmid | 36239881 | en_US |
dc.identifier.scopus | 2-s2.0-85140049481 | en_US |
dc.authorscopusid | 57563127600 | |
dc.authorscopusid | 57452262900 | |
dc.authorscopusid | 6701612705 | |