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Mesenchymal stem cells have ameliorative effect on the colitis model via Nrf2/HO-1 pathway

dc.contributor.authorBozkurt, M.F.
dc.contributor.authorBhaya, M.N.
dc.contributor.authorDibekoğlu, C.
dc.contributor.authorAkat, A.
dc.contributor.authorAteş, U.
dc.contributor.authorErbaş, O.
dc.date.accessioned2022-11-04T19:55:47Z
dc.date.available2022-11-04T19:55:47Z
dc.date.issued2022
dc.identifier.issn0102-8650
dc.identifier.urihttps://doi.org/10.1590/acb370704
dc.identifier.urihttp://hdl.handle.net/11446/4626
dc.description.abstractPurpose: To evaluate the ameliorative effect of mesenchymal stem cells (MSCs) on acetic acid colitis model via Nrf2/HO-1 pathway in rats. Methods: In this study, 30 rats were divided into three groups. Acute colitis was induced by rectal administration of 4% solution of acetic acid. MSCs were injected intraperitoneally in the treatment group. Results: Increased levels of tumor necrosis factor-α (TNF-α), pentraxin-3, and malondialdehyde (MDA) in colitis group were revealed biochemically. Increased level of TNF-α and decreased levels of Nrf2 and interleukin-10 (IL-10) were observed in rectum tissues. Increased fibrous tissue proliferation, vascularization and inflammatory cell infiltration were described in the colitis group. Significant improvement was observed in MSCs treated group histopathologically. Increased immunopositivity of TNF-α, vascular endothelial growth factor (VEGF) and CD68 markers was observed in the colitis group cells, and decreased level of this positivity was observed in MSCs treated group. Conclusion: Biochemical, histopathological and immunohistochemical results strongly support the ameliorative effect of MSCs against acetic induced colitis model via Nrf2/HO-1 pathway in rats. © 2022, Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherSociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgiaen_US
dc.relation.ispartofActa Cirurgica Brasileiraen_US
dc.identifier.doi10.1590/acb370704en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcetic Aciden_US
dc.subjectInflammationen_US
dc.subjectMesenchymal Stem Cellsen_US
dc.subjectNF-E2-Related Factor 2en_US
dc.subjectVascular Endothelial Growth Factor Aen_US
dc.subjectacetic aciden_US
dc.subjectbeta1 integrinen_US
dc.subjectCD68 antigenen_US
dc.subjectendoglinen_US
dc.subjectinterleukin 10en_US
dc.subjectketasolen_US
dc.subjectmalonaldehydeen_US
dc.subjectmicrosomal aminopeptidaseen_US
dc.subjectpenicillin derivativeen_US
dc.subjectpentraxin 3en_US
dc.subjectstreptomycinen_US
dc.subjecttranscription factor Nrf2en_US
dc.subjecttumor necrosis factoren_US
dc.subjectunclassified drugen_US
dc.subjectunclassified drugen_US
dc.subjectvasculotropinen_US
dc.subjectxylazineen_US
dc.subjectinterleukin 10en_US
dc.subjectmalonaldehydeen_US
dc.subjecttranscription factor Nrf2en_US
dc.subjecttumor necrosis factoren_US
dc.subjectvasculotropin Aen_US
dc.subjectadipose tissueen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectArticleen_US
dc.subjectcell growthen_US
dc.subjectcell infiltrationen_US
dc.subjectcell isolationen_US
dc.subjectcell proliferationen_US
dc.subjectcolitisen_US
dc.subjectcontrolled studyen_US
dc.subjectcryopreservationen_US
dc.subjectdisease severityen_US
dc.subjectenzyme linked immunosorbent assayen_US
dc.subjecthistopathologyen_US
dc.subjectimmunofluorescence assayen_US
dc.subjectimmunohistochemistryen_US
dc.subjectinflammationen_US
dc.subjectlipid peroxidationen_US
dc.subjectmacrophageen_US
dc.subjectmaleen_US
dc.subjectmesenchymal stem cellen_US
dc.subjectmorphologyen_US
dc.subjectnonhumanen_US
dc.subjectNrf2 signalingen_US
dc.subjectphotographyen_US
dc.subjectprotein expressionen_US
dc.subjectraten_US
dc.subjectrectal tissueen_US
dc.subjectvascularizationen_US
dc.subjectanimalen_US
dc.subjectcolitisen_US
dc.subjectmetabolismen_US
dc.subjectAnimalsen_US
dc.subjectColitisen_US
dc.subjectInterleukin-10en_US
dc.subjectMalondialdehydeen_US
dc.subjectMesenchymal Stem Cellsen_US
dc.subjectNF-E2-Related Factor 2en_US
dc.subjectRatsen_US
dc.subjectTumor Necrosis Factor-alphaen_US
dc.subjectVascular Endothelial Growth Factor Aen_US
dc.titleMesenchymal stem cells have ameliorative effect on the colitis model via Nrf2/HO-1 pathwayen_US
dc.typearticleen_US
dc.identifier.issue7en_US
dc.identifier.volume37en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-tempBozkurt, M.F., Afyon Kocatepe University, Department of Pathology, Faculty of Veterinary Medicine, Afyonkarahisar, Turkey; Bhaya, M.N., Afyon Kocatepe University, Department of Pathology, Faculty of Veterinary Medicine, Afyonkarahisar, Turkey; Dibekoğlu, C., Istanbul Florence Nightingale Hospital, Department of General Surgery, Istanbul, Turkey; Akat, A., Stembio Cell and Tissue Technologies Inc, Istanbul, Turkey; Ateş, U., Stembio Cell and Tissue Technologies Inc, Istanbul, Turkey; Erbaş, O., Demiroğlu Bilim University, Department of Physiology, Cephalink Institute, Gebze, Turkeyen_US
dc.identifier.pmid36228298en_US
dc.identifier.scopus2-s2.0-85139470289en_US
dc.authorscopusid56511367200
dc.authorscopusid57225073351
dc.authorscopusid6505797608
dc.authorscopusid55986085900
dc.authorscopusid6506910118
dc.authorscopusid55469991100


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