dc.contributor.author | Öztürk, Ç. | |
dc.contributor.author | Paşaoğlu, H.E. | |
dc.contributor.author | Emre, F. | |
dc.contributor.author | Tetikkurt, Ü.S. | |
dc.contributor.author | Ege, T.Ş. | |
dc.date.accessioned | 2022-11-04T19:55:48Z | |
dc.date.available | 2022-11-04T19:55:48Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0392-4203 | |
dc.identifier.uri | https://doi.org/10.23750/abm.v92i6.10432 | |
dc.identifier.uri | http://hdl.handle.net/11446/4630 | |
dc.description.abstract | Background and objectives: The diagnosis of laryngeal squamous cell carcinoma (LSCC) can be made easily based on histopathological findings, but the relationship between morphological findings and prognosis is not clear. In addition to morphological findings, the use of novel markers may contribute to the development of new treatment strategies and improved patient prognosis. CD44, which is a cancer stem cell marker, and Fascin-1, an actin-binding protein has been associated with poor prognosis in many tumors. The aim of this study was to investigate the relationship between CD44 and Fascin-1 expression and clin-icopathologic parameters in LSCC and their roles in the determination of clinical behavior and prognosis. The aim of this study is to investigate whether CD44 and Fascin have a relationship with clinicopathological parameters and have a role in determining clinical behavior and prognosis in LSCC. Methods: 130 patients who were operated in our hospital for LSCC between 2012 and 2018 were included in this study. Fascin-1 and CD44 stains were applied immunohistochemically to the paraffin blocks of the tumors. Immunostained specimens were scored according to the intensity of staining and the percentage of staining for each marker. Overall scores were summed and was designated as immunoreactivity score (IRS). Finally, IRS was catego-rized into two groups; Low and High CD44/Fascin IRS. Results: There were no statistically significant differences between low and high CD44 and Fascin IRS groups in terms of clinicopathologic parameters, overall and disease-free survival (p> 0.05). Conclusion: Immunhistochemical studies are not yet sufficient to predict patient prognosis. Morphological findings still remain of priority and importance for pathologists. (www .actabiomedica.it). © Mattioli 1885. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Mattioli 1885 | en_US |
dc.relation.ispartof | Acta Biomedica | en_US |
dc.identifier.doi | 10.23750/abm.v92i6.10432 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | CD44 | en_US |
dc.subject | Fascin | en_US |
dc.subject | Larynx | en_US |
dc.subject | Squamous cell carcinoma | en_US |
dc.subject | CD44v antigen | en_US |
dc.subject | fascin | en_US |
dc.subject | Hermes antigen | en_US |
dc.subject | messenger RNA | en_US |
dc.subject | paraffin | en_US |
dc.subject | actin binding protein | en_US |
dc.subject | carrier protein | en_US |
dc.subject | CD44 protein, human | en_US |
dc.subject | fascin | en_US |
dc.subject | hyaluronic acid binding protein | en_US |
dc.subject | adult | en_US |
dc.subject | aged | en_US |
dc.subject | Article | en_US |
dc.subject | cancer patient | en_US |
dc.subject | cancer prognosis | en_US |
dc.subject | cancer staging | en_US |
dc.subject | cancer stem cell | en_US |
dc.subject | cancer survival | en_US |
dc.subject | disease free survival | en_US |
dc.subject | female | en_US |
dc.subject | gene expression | en_US |
dc.subject | histology | en_US |
dc.subject | histopathology | en_US |
dc.subject | immune response | en_US |
dc.subject | immunohistochemistry | en_US |
dc.subject | immunoreactivity | en_US |
dc.subject | laryngectomy | en_US |
dc.subject | larynx squamous cell carcinoma | en_US |
dc.subject | life expectancy | en_US |
dc.subject | lymph node metastasis | en_US |
dc.subject | major clinical study | en_US |
dc.subject | male | en_US |
dc.subject | mouth squamous cell carcinoma | en_US |
dc.subject | overall survival | en_US |
dc.subject | perineural invasion | en_US |
dc.subject | polysomnography | en_US |
dc.subject | protein expression | en_US |
dc.subject | scoring system | en_US |
dc.subject | squamous cell carcinoma | en_US |
dc.subject | survival rate | en_US |
dc.subject | tumor growth | en_US |
dc.subject | head and neck tumor | en_US |
dc.subject | human | en_US |
dc.subject | prognosis | en_US |
dc.subject | squamous cell carcinoma | en_US |
dc.subject | Carcinoma, Squamous Cell | en_US |
dc.subject | Carrier Proteins | en_US |
dc.subject | Head and Neck Neoplasms | en_US |
dc.subject | Humans | en_US |
dc.subject | Hyaluronan Receptors | en_US |
dc.subject | Microfilament Proteins | en_US |
dc.subject | Prognosis | en_US |
dc.subject | Squamous Cell Carcinoma of Head and Neck | en_US |
dc.title | Do Immunohistochemical Studies Have a Role in Predicting Prognosis of Laryngeal Squamous Cell Carcinomas? CD44 and Fascin Experience | en_US |
dc.type | article | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.volume | 92 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | Öztürk, Ç., Recep Tayyip Erdogan University Training and Research Hospital, Pathology Department, Rize, Merkez, Rize, Turkey; Paşaoğlu, H.E., University of Health Sciences Bagcilar Traning and Research Hospital, Pathology Department, İstanbul, Turkey; Emre, F., University of Health Sciences Bagcilar Traning and Research Hospital, Pathology Department, İstanbul, Turkey; Tetikkurt, Ü.S., Demiroglu Bilim University Medical Faculty, Pathology Department, İstanbul, Turkey; Ege, T.Ş., University of Health Sciences Bagcilar Traning and Research Hospital, Otolaryngology Department, İstanbul, Turkey | en_US |
dc.identifier.pmid | 35075092 | en_US |
dc.identifier.scopus | 2-s2.0-85123901217 | en_US |
dc.authorscopusid | 57226135313 | |
dc.authorscopusid | 57436580300 | |
dc.authorscopusid | 54892625900 | |
dc.authorscopusid | 6506434119 | |
dc.authorscopusid | 57451202100 | |