| dc.description.abstract | Introduction: This study aimed to determine the utility of different methods to predict rapid progressors (RPs) and their clinical characteristics in Asia-Pacific patients with autosomal dominant polycystic kidney disease (ADPKD). Methods: This was a multinational retrospective observational cohort study of patients with ADPKD in the Asia-Pacific region. Five hospitals from Australia, China, South Korea, Taiwan, and Turkey participated in this study. RP was defined by European Renal Association-European Dialysis and Transplantation Association (ERA-EDTA) guidelines and compared to slow progressors (SPs). Results: Among 768 patients, 426 patients were RPs. Three hundred six patients met only 1 criterion and 120 patients satisfied multiple criteria for RP. Historical estimated glomerular filtration rate (eGFR) decline fulfilled the criteria for RP in 210 patients. Five patients met the criteria for a historical increase in height adjusted total kidney volume (TKV). The 210 patients satisfied the criteria for based on kidney volume. During the follow-up period, cyst infections, cyst hemorrhage, and proteinuria occurred more frequently in RP; and 13.9% and 2.1% of RPs and SPs, respectively, progressed to end-stage kidney disease (ESKD). RP criteria based on historical eGFR decline had the strongest correlation with eGFR change over a 2-year follow-up Conclusion: Various assessment strategies should be used for identifying RPs among Asian-Pacific patients with ADPKD in real-world clinical practice during the follow-up period, cyst infections, cyst hemorrhage, and proteinuria occurred more frequently; and more patients progressed to ESKD in RPs compared with SPs. | en_US |
| dc.department-temp | [Oh, Yun Kyu] Seoul Metropolitan Govt Seoul Natl Univ Boramae M, Dept Internal Med, Seoul, South Korea; [Oh, Yun Kyu; Ryu, Hyunjin; Ahn, Curie] Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; [Park, Hayne C.] Kangnam Sacred Heart Hosp, Dept Internal Med, Seoul, South Korea; [Ma, Yiyi; Xu, Dechao] Navy Med Univ, Kidney Inst, Affiliated Hosp 2, Dept Nephrol, Shanghai, Peoples R China; [Ecder, Tevfik] Istanbul Bilim Univ, Div Nephrol, Dept Internal Med, Fac Med, Istanbul, Turkiye; [Kao, Tze-Wah] Fu Jen Catholic Univ Hosp, Fu Jen Catholic Univ, Div Nephrol, Dept Internal Med, New Taipei, Taiwan; [Huang, Jeng-Wen] Natl Taiwan Univ, Div Nephrol, Dept Internal Med, Coll Med, Taipei, Taiwan; [Huang, Jeng-Wen] Natl Taiwan Univ, Coll Med, Taipei, Taiwan; [Rangan, Gopala K.] Univ Sydney, Westmead Inst Med Res, Michael Stern Lab Polycyst Kidney Dis, Westmead, NSW, Australia; [Rangan, Gopala K.] Western Sydney Local Hlth Dist, Westmead Hosp, Dept Renal Med, Westmead, NSW, Australia | en_US |
