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dc.contributor.authorNagler, Arnon
dc.contributor.authorLabopin, Myriam
dc.contributor.authorSwoboda, Ryszard
dc.contributor.authorPioltelli, Pietro
dc.contributor.authorArat, Mutlu
dc.contributor.authorYakoub-Agha, Ibrahim
dc.contributor.authorKulagin, Alexander
dc.date.accessioned2024-02-04T13:29:44Z
dc.date.available2024-02-04T13:29:44Z
dc.date.issued2022
dc.identifier.issn2572-9241
dc.identifier.urihttps://doi.org/10.1097/HS9.0000000000000790
dc.identifier.urihttp://hdl.handle.net/11446/4736
dc.description.abstractThe results of haploidentical stem cell transplantation (haploHCT) for patients with acute lymphoblastic leukemia (ALL) transplanted in active disease remain largely unknown. We retrospectively analyzed adult patients with R/R ALL who underwent haploHCT or matched sibling donor (MSD-HCT) as a first transplantation between 2012 and 2020. The analysis comprised 274 patients, 94 had a haploHCT, and 180 had an MSD-HCT. The median follow-up was 32 months. The median age was 33 (range 18-76) and 37 (18-76) years in the haplo- and MSD-HCT groups, respectively. Post-transplant cyclophosphamide (PTCy) was used in 88% of haploHCT and in 4% of the MSD-HCT group. Graft-versus-host disease grade III-IV was higher in haploHCT than in the MSD-HCT group (18% versus 9%; P = 0.042). The 2-year chronic (c) graft-versus-host disease rates were 17% versus 33% (hazard ratio [HR] = 0.56; P = 0.14), respectively. By multivariate analysis, relapse incidence, and leukemia-free survival were not significatively different between the transplant groups, while nonrelapse mortality (NRM) was significantly higher (25% versus 18% at 2 years; HR = 2.03; P = 0.042) and overall survival (OS) lower (22% versus 38% at 2 years; HR = 1.72; P = 0.009) in the haploHCT group compared with the MSD-HCT group. We conclude that the 2-year OS of R/R ALL patients undergoing MSD transplants is significantly better than in haploHCT with a higher NRM in the latter.en_US
dc.language.isoengen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofHemasphereen_US
dc.identifier.doi10.1097/HS9.0000000000000790
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleHaploidentical Versus Matched Sibling Donor Hematopoietic Stem Cell Transplantation for Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia: A Study From the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantationen_US
dc.typearticleen_US
dc.departmentDBÜen_US
dc.identifier.issue11en_US
dc.identifier.volume6en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-temp[Nagler, Arnon] Sheba Med Ctr, Div Hematol, Tel Hashomer, Israel; [Labopin, Myriam] ALWP EBMT Paris Off, Paris, France; [Labopin, Myriam] Sorbonne Univ, St Antoine Hosp, INSERM, UMR 938,Dept Haematol, Paris, France; [Swoboda, Ryszard; Giebel, Sebastian] Maria Sklodowska Curie Natl Res Inst Oncol, Dept Bone Marrow Transplantat & Oncohematol, Gliwice Branch, Gliwice, Poland; [Pioltelli, Pietro] Univ Milano Biocca, Clin Ematol, Osped San Gerardo, Monza, Italy; [Arat, Mutlu] Demiroglu Bilim Univ, Istanbul Florence Nightingale Hosp, Hematopoiet SCT Unit, Istanbul, Turkey; [Yakoub-Agha, Ibrahim] Univ Lille, CHU Lille LIRIC, INSERM, U995, Lille, France; [Kulagin, Alexander] Pavlov Univ, RM Gorbacheva Res Inst, St Petersburg, Russia; [Maria Raiola, Anna] IRCCS Osped Policlin, Ematol & Terapie Cellulari, Genoa, Italy; [Ozdogu, Hakan] Baskent Univ Hosp, Haematol Div, BMT Unit, Hematol Res Lab,Training & Med, Adana, Turkey; [Risitano, Antonio] AORN SAN G MOSCATI, Ematol, Avellino, Italy; [Nur Ozkurt, Zubeyde] Gazi Univ, Fac Med, Hematol, Ankara, Turkey; [Sanz, Jaime] Hosp Univ & Politecn La Fe, Valencia, Spain; [Brissot, Eolia; Giebel, Sebastian] Sorbonne Univ, Hop St Antoine, INSERM, UMRs 938,Serv Hematol Clin & Therapie Cellulaire, Paris, France; [Zina, Peric] Univ Zagreb, Univ Hosp Ctr Zagreb, Sch Med, Zagreb, Croatia; [Ciceri, Fabio] Oen_US
dc.authoridSanz, Jaime/0000-0001-6934-4619
dc.authoridKulagin, Alexander D./0000-0002-9589-4136
dc.authoridMohty, Mohamad/0000-0002-7264-808X
dc.identifier.pmid36258924en_US
dc.identifier.scopus2-s2.0-85149825044en_US
dc.identifier.wosWOS:000892089600008en_US
dc.authorwosidSanz, Jaime/K-7141-2019
dc.authorwosidYakoub-Agha, Ibrahim/R-7872-2018
dc.authorwosidKulagin, Alexander D./L-9795-2014


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