dc.description.abstract | In this registry-based study, we compared outcomes of allogeneic hematopoietic cell transplantation (allo-HCT) in adult patients with acute lymphoblastic leukemia (ALL) transplanted in first complete remission (CR-1), following conditioning with total body irradiation (TBI) at a standard 12-Gray or at a lower 8-Gray total dose. Patients received fludarabine (flu) as the sole chemotherapy complementing TBI. Eight-Gray TBI/flu was used in 494 patients and 12-Gray TBI/flu in 145 patients. Eighty-eight (23.1%) and 36 (29%) of the patients had Ph-negative B-ALL, 222 (58.3%) and 53 (42.7%) had Ph-positive B-ALL, 71 (18.6%) and 35 (28.2%) T-ALL, respectively (P = 0.008). Patients treated with 8-Gray were older than ones received 12-Gray (median 55.7 versus 40.3 years, P < 0.0001) and were more frequently administered in vivo T-cell depletion (71% versus 40%, P <0.0001). In a multivariate model adjusted for age, type of ALL, and other prognostic factors, leukemia-free survival (primary endpoint) as well as relapse, nonrelapse mortality, overall survival, and GVHD-free, relapse-free survival were not influenced by the TBI dose. These results were confirmed when we focused on patients <55 years of age (median 47 years). Patients with Ph-positive ALL or T-ALL had significantly better survival outcomes than ones with Ph-negative B-ALL, mainly due to significantly fewer relapses. We conclude that 8-Gray TBI is sufficient for adult patients with ALL transplanted in CR-1 with no additional benefit of augmenting the conditioning intensity to 12-Gray. | en_US |
dc.department-temp | [Spyridonidis, Alexandros] Univ Patras, Bone Marrow Transplantat Unit, Patras, Greece; [Spyridonidis, Alexandros] Univ Patras, Inst Cellular Therapy, Patras, Greece; [Labopin, Myriam; Mohty, Mohamad] Sorbonne Univ, St Antoine Hosp, AP HP, INSERM UMRs 938, Paris, France; [Savani, Bipin] Vanderbilt Univ, Med Ctr, Nashville, TN USA; [Giebel, Sebastian] Mar Sklodowska Curie Natl Res Inst Oncol, Gliwice, Poland; [Bug, Gesine] Goethe Univ, Dept Med 2, Hematol, Med Oncol, Frankfurt, Germany; [Schoenland, Stefan] Univ Hosp Heidelberg, Med Dept 5, Heidelberg, Germany; [Kroeger, Nicolaus] Univ Med Ctr, Dept Stem Cell Transplantat, Hamburg, Germany; [Stelljes, Matthias] Univ Munster, Dept Hematol Oncol, Munster, Germany; [Schroeder, Thomas] Univ Hosp, Dept Bone Marrow Transplantat, Essen, Germany; [McDonald, Andrew] Netcare Pretoria East Hosp, Alberts Cellular Therapy, Pretoria, South Africa; [Blau, Igor-Wolfgang] Charite Univ Med Berlin, Berlin, Germany; [Bornhaeuser, Martin] Tech Univ Dresden, Univ Hosp, Dresden, Germany; [Rovira, Montse] Josep Carreras Inst, Inst Hematol & Oncol, Hematol Dept, BMT Unit, Barcelona, Spain; [Bethge, Wolfgang] Univ Hosp Tuebingen, Med Ctr, Dept Hematol & Oncol, Tubingen, Germany; [Neubauer, Andreas] Philipps Univ Marburg, Univ Hosp Giessen & Marburg, Marburg, Germany; [Ganser, Arnold] Hannover Med Sch, Hann | en_US |