dc.contributor.author | Yalcin, Mehmet Burak | |
dc.contributor.author | Bora, Ejder Saylav | |
dc.contributor.author | Cakir, Adem | |
dc.contributor.author | Akbulut, Sabiye | |
dc.contributor.author | Erbas, Oytun | |
dc.date.accessioned | 2024-02-04T13:29:49Z | |
dc.date.available | 2024-02-04T13:29:49Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 0102-8650 | |
dc.identifier.issn | 1678-2674 | |
dc.identifier.uri | https://doi.org/10.1590/acb387823 | |
dc.identifier.uri | http://hdl.handle.net/11446/4759 | |
dc.description.abstract | Purpose: To evaluate the neuroprotective effects of Rilmenidine on diabetic peripheral neuropathy (DPN) in a rat model of diabetes induced by streptozotocin (STZ). Methods: STZ (60 mg/kg) was administered to adult Sprague-Dawley rats to induce diabetes. On the 30th day after STZ administration, electromyography (EMG) and motor function tests confirmed the presence of DPN. Group 1: Control (n = 10), Group 2: DM + 0.1 mg/kg Rilmenidine (n = 10), and Group 3: DM + 0.2 mg/kg Rilmenidine (n = 10) were administered via oral lavage for four weeks. EMG, motor function test, biochemical analysis, and histological and immunohistochemical analysis of sciatic nerves were then performed. Results: The administration of Rilmenidine to diabetic rats substantially reduced sciatic nerve inflammation and fibrosis and prevented electrophysiological alterations. Immunohistochemistry of sciatic nerves from saline-treated rats revealed increased perineural thickness, HMGB-1, tumor necrosis factor-alpha, and a decrease in nerve growth factor (NGF), LC-3. In contrast, Rilmendine significantly inhibited inflammation markers and prevented the reduction in NGF expression. In addition, Rilmenidine significantly decreased malondialdehyde and increased diabetic rats' total antioxidative capacity. Conclusion: The findings of this study suggest that Rilmenidine may have therapeutic effects on DNP by modulating antioxidant and autophagic pathways. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Acta Cirurgica Brasileira | en_US |
dc.relation.ispartof | Acta Cirurgica Brasileira | en_US |
dc.identifier.doi | 10.1590/acb387823 | |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Diabetic Neuropathies | en_US |
dc.subject | Rilmenidine | en_US |
dc.subject | Electromyography | en_US |
dc.subject | Autophagy | en_US |
dc.title | Autophagy and anti-inflammation ameliorate diabetic neuropathy with Rilmenidine | en_US |
dc.type | article | en_US |
dc.department | DBÜ | en_US |
dc.identifier.volume | 38 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Yalcin, Mehmet Burak] Bahcelievler Mem Hosp, Dept Orthoped & Traumatol, Istanbul, Turkiye; [Bora, Ejder Saylav] Izmir Ataturk Res & Training Hosp, Dept Emergency Med, Izmir, Turkiye; [Cakir, Adem] Canakkale Mehmet Akif Ersoy State SBU Kartal Kosuy, Dept Emergency Med, Canakkale, Turkiye; [Akbulut, Sabiye] SBU Kartal Kosuyolu Training & Res Hosp, Dept Gastroenterol, Istanbul, Turkiye; [Erbas, Oytun] Demiroglu Bilim Univ, Fac Med, Dept Physiol, Istanbul, Turkiye | en_US |
dc.authorid | Yalcin, Mehmet Burak/0000-0003-1016-452X | |
dc.authorid | Bora, Ejder Saylav/0000-0002-2448-2337 | |
dc.authorid | CAKIR, Adem/0000-0002-4966-4882 | |
dc.identifier.pmid | 38055406 | en_US |
dc.identifier.scopus | 2-s2.0-85178905574 | en_US |
dc.identifier.wos | WOS:001123785900001 | en_US |
dc.authorwosid | Yalcin, Mehmet Burak/AAY-5740-2020 | |
dc.authorwosid | Bora, Ejder Saylav/AAA-9882-2021 | |