dc.contributor.author | Sokmen, Bedriye Koyuncu | |
dc.contributor.author | Inan, Nagihan | |
dc.date.accessioned | 2024-02-04T13:29:49Z | |
dc.date.available | 2024-02-04T13:29:49Z | |
dc.date.issued | 2024 | |
dc.identifier.issn | 1573-4056 | |
dc.identifier.issn | 1875-6603 | |
dc.identifier.uri | https://doi.org/10.2174/1573405620666230508105758 | |
dc.identifier.uri | http://hdl.handle.net/11446/4762 | |
dc.description.abstract | Background: Distinguishing between IHCC and HCC is important because of their differences in treatment and prognosis. The hybrid Positron Emission Tomography/magnetic Resonance Imaging (PET/MRI) system has become more widely accessible, with oncological imaging becoming one of its most promising applications. Objective: The objective of this study was to see how well 18F-fluorodeoxyglucose (18F-FDG) PET/MRI could be used for differential diagnosis and histologic grading of primary hepatic malignancies. Methods: We retrospectively evaluated 64 patients (53 patients with HCC, 11 patients with IHCC) with histologically proven primary hepatic malignancies using 18F-FDG/MRI. The Apparent Diffusion Coefficient (ADC), Coefficient of Variance (CV) of the ADC, and standardized uptake value (SUV) were calculated. Results: The mean SUVmax value was higher for IHCC (7.7 +/- 3.4) than for HCC (5.2 +/- 3.1) (p = 0.019). The area under the curve (AUC) was 0.737, an optimal 6.98 cut-off value providing 72% sensitivity and 79% specificity. The ADCcv value in IHCC was statistically significantly higher than in HCC (p=0.014). ADC mean values in HCCs were significantly higher in low-grade tumors than in high-grade tumors. The AUC value was 0.73, and the optimal cut-off point was 1.20x10-6 mm(2)/s, giving 62% sensitivity and 72% specificity. The SUVmax value was also found to be statistically significantly higher in the high-grade group. The ADCcv value in the HCC low-grade group was found to be lower than in the high-grade group (p=0.036). Conclusion: 18F FDG PET/MRI is a novel imaging technique that can aid in the differentiation of primary hepatic neoplasms as well as tumor-grade estimation. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Bentham Science Publ Ltd | en_US |
dc.relation.ispartof | Current Medical Imaging | en_US |
dc.identifier.doi | 10.2174/1573405620666230508105758 | |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Hepatocellular carcinoma | en_US |
dc.subject | Cholangiocarcinoma | en_US |
dc.subject | Histopathology | en_US |
dc.subject | Positron emission tomography | en_US |
dc.subject | Magnetic resonance imaging | en_US |
dc.subject | CV | en_US |
dc.title | 18 F-FDG PET/MRI of Primary Hepatic Malignancies: Differential Diagnosis and Histologic Grading | en_US |
dc.type | article | en_US |
dc.department | DBÜ | en_US |
dc.identifier.volume | 20 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Sokmen, Bedriye Koyuncu] Acbadem Atakent Hosp, Dept Radiol, Istanbul, Turkiye; [Inan, Nagihan] Istanbul Florence Nightingale Hosp, Demiroglu Bilim Univ, Dept Radiol, Istanbul, Turkiye | en_US |
dc.identifier.pmid | 37157218 | en_US |
dc.identifier.scopus | 2-s2.0-85167853674 | en_US |
dc.identifier.wos | WOS:001085241200009 | en_US |