dc.contributor.author | Bora, Ejder Saylav | |
dc.contributor.author | Erdogan, MuMIN Alper | |
dc.contributor.author | Ozkul, Bahattin | |
dc.contributor.author | Sever, Ibrahim Halil | |
dc.contributor.author | Sogut, Ibrahim | |
dc.contributor.author | Hurdag, Canan | |
dc.contributor.author | Erbas, Oytun | |
dc.date.accessioned | 2024-02-04T13:29:51Z | |
dc.date.available | 2024-02-04T13:29:51Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 0327-9545 | |
dc.identifier.issn | 1667-5746 | |
dc.identifier.uri | https://doi.org/10.32604/biocell.2022.018510 | |
dc.identifier.uri | http://hdl.handle.net/11446/4768 | |
dc.description.abstract | Purpose: Digitoxin is a cardiac glycoside used in the treatment of heart failure. Inspired by its known antiinflammatory effect, this study aims to investigate the effect of digoxin in a sepsis model and to bring to light its effect and underlying mechanism in acute lung injury (ALI). Method: 28 wistar albino rats were divided into 4 groups. Sepsis model is performed by the feces intraperitoneal-injection procedure (FIP). Results: TNF-a, CRP, IL-6, IL 1-Beta, lactic acid, and MDA values were significantly decreased in the FIP+digitoxin group compared to the FIP+Saline group. When the same groups were examined, histological improvements such as decrease in alveolar inflammation and decrease in septal thickening in the digitoxin group and thorax CT were found to be significantly higher in the Hounsfield unit digitoxin group compared to the Saline group. Conclusion: Digitoxin has shown biochemical improvement in sepsis with all known mechanisms of action, and healing effects in both computerized tomography and histology in the lung. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Tech Science Press | en_US |
dc.relation.ispartof | Biocell | en_US |
dc.identifier.doi | 10.32604/biocell.2022.018510 | |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Digitoxin | en_US |
dc.subject | Animal model | en_US |
dc.subject | Sepsis | en_US |
dc.subject | Acute lung injury | en_US |
dc.title | Short term protective effect of digitoxin in sepsis-induced acute lung injury | en_US |
dc.type | article | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.volume | 46 | en_US |
dc.identifier.startpage | 433 | en_US |
dc.identifier.endpage | 439 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Bora, Ejder Saylav] Izmir Ataturk Res & Training Hosp Emergency Med, Izmir, Turkey; [Erdogan, MuMIN Alper] Izmir Katip Celebi Univ, Dept Physiol, Izmir, Turkey; [Ozkul, Bahattin] Istanbul Atlas Univ, Dept Radiol, Istanbul, Turkey; [Sever, Ibrahim Halil] Demiroglu Bilim Univ, Dept Radiol, Istanbul, Turkey; [Sogut, Ibrahim] Demiroglu Bilim Univ, Dept Biochem, Istanbul, Turkey; [Hurdag, Canan] Demiroglu Bilim Univ, Dept Histol & Embryol, Istanbul, Turkey; [Erbas, Oytun] Demiroglu Bilim Univ, Dept Physiol, Istanbul, Turkey | en_US |
dc.authorid | Bora, Ejder Saylav/0000-0002-2448-2337 | |
dc.authorid | Özkul, Bahattin/0000-0003-3339-8329 | |
dc.authorid | Erbas, Oytun/0000-0001-5427-8428 | |
dc.identifier.scopus | 2-s2.0-85122861931 | en_US |
dc.identifier.wos | WOS:000710086100013 | en_US |
dc.authorwosid | Bora, Ejder Saylav/AAA-9882-2021 | |
dc.authorwosid | Özkul, Bahattin/JVN-8696-2024 | |