dc.contributor.author | Yalcin, Mehmet Burak | |
dc.contributor.author | Bora, Ejder Saylav | |
dc.contributor.author | Erdogan, Muemin Alper | |
dc.contributor.author | Cakir, Adem | |
dc.contributor.author | Erbas, Oytun | |
dc.date.accessioned | 2024-02-04T13:29:52Z | |
dc.date.available | 2024-02-04T13:29:52Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 2077-0383 | |
dc.identifier.uri | https://doi.org/10.3390/jcm12196411 | |
dc.identifier.uri | http://hdl.handle.net/11446/4776 | |
dc.description.abstract | Peripheral nerve damage is a significant clinical problem with limited therapeutic options. Adipose-derived mesenchymal stem cells (ADSCs) have emerged as a promising therapeutic approach due to their regenerative potential. However, the underlying mechanisms by which ADSCs promote peripheral nerve regeneration remain unclear. In this study, we investigated the role of syndecan-1 and heat shock protein 70 (HSP-70) in mediating the regenerative effects of ADSCs on peripheral nerves. ADSCs were characterized and isolated from the adipose tissue of rats. In vitro experiments were conducted to evaluate the ability of ADSCs to secrete syndecan-1 and HSP-70 in response to stress conditions. To evaluate the therapeutic potential of ADSCs, rats with sciatic nerve injuries were treated with ADSCs and assessed for functional recovery, nerve regeneration, and changes in syndecan-1 and HSP-70 levels. Regeneration was evaluated with Electromyography (EMG) histology. The results showed that ADSCs could secrete syndecan-1 and HSP-70 in response to stress conditions. Furthermore, ADSC treatment significantly improved functional recovery and nerve regeneration and increased syndecan-1 and HSP-70 levels in the injured nerve. On the other hand, ADSCs make improvements histologically through the influence of Nerve growth factor (NGF), Malondialdehyde (MDA), and EMG. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Mdpi | en_US |
dc.relation.ispartof | Journal Of Clinical Medicine | en_US |
dc.identifier.doi | 10.3390/jcm12196411 | |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Adipose-derived mesenchymal stem cell | en_US |
dc.subject | nerve damage | en_US |
dc.subject | syndecan-1 | en_US |
dc.subject | HSP-70 | en_US |
dc.subject | regeneration | en_US |
dc.title | The Effect of Adipose-Derived Mesenchymal Stem Cells on Peripheral Nerve Damage in a Rodent Model | en_US |
dc.type | article | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 19 | en_US |
dc.identifier.volume | 12 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Yalcin, Mehmet Burak] Bahcelievler Mem Hosp, Dept Orthoped & Traumatol, TR-34180 Istanbul, Turkiye; [Bora, Ejder Saylav] Izmir Ataturk Res & Training Hosp, Dept Emergency Med, TR-35360 Izmir, Turkiye; [Erdogan, Muemin Alper] Izmir Katip Celebi Univ, Fac Med, Dept Physiol, TR-35620 Izmir, Turkiye; [Cakir, Adem] Canakkale Mehmet Akif Ersoy State Hosp, Dept Emergency Med, TR-17100 Canakkale, Turkiye; [Erbas, Oytun] Demiroglu Bilim Univ, Dept Physiol, TR-34394 Istanbul, Turkiye | en_US |
dc.authorid | Bora, Ejder Saylav/0000-0002-2448-2337 | |
dc.authorid | Yalcin, Mehmet Burak/0000-0003-1016-452X | |
dc.authorid | CAKIR, Adem/0000-0002-4966-4882 | |
dc.authorid | Erdogan, Mumin/0000-0003-0048-444X | |
dc.identifier.pmid | 37835055 | en_US |
dc.identifier.scopus | 2-s2.0-85173907093 | en_US |
dc.identifier.wos | WOS:001082913800001 | en_US |
dc.authorwosid | Bora, Ejder Saylav/AAA-9882-2021 | |
dc.authorwosid | Yalcin, Mehmet Burak/AAY-5740-2020 | |