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dc.contributor.authorYaka, Ebru Bellioglu
dc.contributor.authorYazici, Zeynep Mine Coskun
dc.contributor.authorErsoz, Melike
dc.contributor.authorGulsoy, Nagihan
dc.date.accessioned2024-02-04T13:29:53Z
dc.date.available2024-02-04T13:29:53Z
dc.date.issued2023
dc.identifier.issn1011-601X
dc.identifier.urihttps://doi.org/10.36721/PJPS.2023.36.1.REG.059-066.1
dc.identifier.urihttp://hdl.handle.net/11446/4777
dc.description.abstractIn our study, the effects of gallic acid (GA), a natural therapeutic agent, on oxidative stress biomarkers and MMP-2 and MMP-9 expressions via the p38/JNK pathway in C6 glioma cells were investigated. The toxicity of GA was determined by the WST-1 method. JNK, p38 and MMP-2/-9 mRNA expressions in the cell line were detected by RT-qPCR. JNK/SAPK, Grap-2/p38 and MMP-2/-9 protein levels were analyzed by using ELISA methods. Biochemical markers were analyzed. GA reduced the cell viability of C6 glioma cells after 24, 48 and 72h of treatment. The expression levels of MMP-2 and MMP-9 mRNA decreased in C6 glioma cells treated with 150 mu g/ml GA for 24 and 48h compared to the control cells. Unlike SOD activity, GA treatment significantly increased PCO and MDA levels in the cells treated with 150 mu g/ml GA for 24 and 48h compared to the non-treated cells. According to our results, GA inhibited the proliferation of C6 glioma cells. Also, it reduced MMP-2 and MMP-9 expressions and increase oxidative stress. Therefore, GA may have preventive effects on gliomas progression and/or invasion.en_US
dc.language.isoengen_US
dc.publisherUniv Karachien_US
dc.relation.ispartofPakistan Journal Of Pharmaceutical Sciencesen_US
dc.identifier.doi10.36721/PJPS.2023.36.1.REG.059-066.1
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMatrix metalloproteinaseen_US
dc.subjectoxidative damageen_US
dc.subjectgallic aciden_US
dc.subjectgliomaen_US
dc.subjecttoxicityen_US
dc.titleEffects of gallic acid on expressions of MMP-2 and MMP-9 through the pathway of p38/JNK in C6 glioma cellsen_US
dc.typearticleen_US
dc.departmentDBÜen_US
dc.identifier.issue1en_US
dc.identifier.volume36en_US
dc.identifier.startpage59en_US
dc.identifier.endpage66en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-temp[Yaka, Ebru Bellioglu] Marmara Univ, Inst Pure & Appl Sci, Dept Biol, Istanbul, Turkiye; [Yazici, Zeynep Mine Coskun; Ersoz, Melike] Demiroglu Bilim Univ, Fac Arts & Sci, Dept Mol Biol & Genet, Istanbul, Turkiye; [Gulsoy, Nagihan] Marmara Univ, Fac Arts & Sci, Dept Biol, Istanbul, Turkiyeen_US
dc.identifier.pmid36967497en_US
dc.identifier.scopus2-s2.0-85151044574en_US
dc.identifier.wosWOS:000921331400008en_US
dc.authorwosidGülsoy, Nagihan/JVO-4616-2024


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