dc.contributor.author | Aferin, Ugur | |
dc.contributor.author | Bahtiyar, Nurten | |
dc.contributor.author | Onaran, Ilhan | |
dc.contributor.author | Ozkara, Hamdi | |
dc.date.accessioned | 2024-02-04T13:29:53Z | |
dc.date.available | 2024-02-04T13:29:53Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 1124-3562 | |
dc.identifier.issn | 2282-4197 | |
dc.identifier.uri | https://doi.org/10.4081/aiua.2023.11610 | |
dc.identifier.uri | http://hdl.handle.net/11446/4778 | |
dc.description.abstract | Background: We sought to determine whether two soluble forms with different size of mtDNA are linked to prostatic inflammation, and whether they discriminate prostate cancer (PCa) from inflammatory prostatic conditions.Methods: Histopathologically diagnosed prostatitis, PCa and benign prostatic hyperplasia patients (n = 93) were enrolled in this study and they were categorized as with and without prostate inflammation. Quantitative RT-PCR was used to analyze the levels of 79-bp and 230-bp fragments in urine and blood samples collected following prostate massage.Results: The urine mtDNA-79 and mtDNA-230 were significantly increased in patients with prostate inflammation compared with those in without inflammation. Here, 79-bp fragment of apoptotic origin was significantly higher level than 230-bp fragment of necrotic origin. Although mtDNA-79 copy number in serum samples was also increased in patients with prostate inflammation, mtDNA-230 was similar in the two groups. Furthermore, mtDNA-79 and mtDNA-230 copy numbers in postprostate massage urine were higher (about 16-fold and 22-fold, respectively) than those from serum samples. ROC analysis showed that, although post-prostate massage urine have relatively higher performance than blood, ability to discriminate cases of both fragments was not better than that of serum total PSA.Conclusions: Our results demonstrate that shorter cf-mtDNA fragment size in particular, increase in the presence of prostate inflammation in post-prostatic massage urine but both fragments could never improve serum total PSA performance. | en_US |
dc.description.sponsorship | Research Fund of the Istanbul University-Cerrahpasa [30381] | en_US |
dc.description.sponsorship | The present study was supported by the Research Fund of the Istanbul University-Cerrahpasa (Grant no. 30381) . | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Pagepress Publ | en_US |
dc.relation.ispartof | Archivio Italiano Di Urologia E Andrologia | en_US |
dc.identifier.doi | 10.4081/aiua.2023.11610 | |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | KEY WORDS | en_US |
dc.subject | Prostate | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Cancer | en_US |
dc.subject | Mitochondrial DNA | en_US |
dc.subject | Post-prostatic massage | en_US |
dc.title | Are elevated mitochondrial DNA fragments in prostatic inflammation a potential biomarker for prostate cancer? | en_US |
dc.type | article | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.volume | 95 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | [Aferin, Ugur] Demiroglu Bilim Univ, Med Fac, Dept Urol, Istanbul, Turkiye; [Bahtiyar, Nurten] Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Dept Biophys, Istanbul, Turkiye; [Onaran, Ilhan] Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Dept Med Biol, Istanbul, Turkiye; [Ozkara, Hamdi] Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Dept Urol, Istanbul, Turkiye | en_US |
dc.authorid | Onaran, Ilhan/0000-0003-4630-9516 | |
dc.identifier.pmid | 37791550 | en_US |
dc.identifier.scopus | 2-s2.0-85173049726 | en_US |
dc.identifier.wos | WOS:001083764400011 | en_US |
dc.authorwosid | BAHTİYAR, NURTEN/IZP-9481-2023 | |