Ameliorating Effect of Propofol on Cisplatin -Induced Liver and Kidney Damage in Rats

Abstract

Background and Objective: Cisplatin is among the most frequently used in solid organ cancers. However, it can be dose-limiting, especially due to its side effects on the kidney and liver. This study aims to examine the protective properties of propofol from cisplatin-induced kidney and liver damage. Materials and Methods:A total of 24 adult female rats were included in the study and divided into 3 groups, each containing 8 rats. The 1st group was the control group. The 2nd group was administered 2.5 mg/kg/day of cisplatin 2 days a week for 4 weeks. In the 3rd group, as for that, in addition to the 2nd group, 10 mg kg(-1) of propofol daily was injected intraperitoneally for 4 weeks. Blood-urea nitrogen (BUN), Alanine Aminotransferase (ALT), malondialdehyde (MDA), which was used for oxidative stress parameter and inflammatory cytokines (Tumor Necrosis Factor (TNF)-alpha and Interleukin (IL)-6) were analyzed in all three groups. In addition to these,all groups were examined histopathologically. Results:A significant increase was observed in BUN, IL-6, MDA and TNF-alpha levels after cisplatin treatment. With the addition of propofol to the treatment, on the other hand, a significant decrease was obtained in all parameters. Histopathologically, it was observed that propofol reduced the damage caused by cisplatin in liver and kidney tissue and its cytoprotective property was observed immunohistochemically through the increase in HSP-70 protein. Conclusion: Consequently, propofol has protective properties from cisplatin-induced nephrotoxicity and hepatotoxicity. It not only reduces oxidative stress and inflammation but also reverses damage in tissue through the increase of HSP-70.