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dc.contributor.authorEbrahimzadeh, Mina
dc.contributor.authorPehlivanoglu, Cemil
dc.contributor.authorOzgur, Burcin Aydin
dc.contributor.authorKucuksezer, Umut Can
dc.contributor.authorDegirmencioglu, Sevgin
dc.contributor.authorTekin, Sakin
dc.contributor.authorCakmak, Ramazan
dc.date.accessioned2024-02-04T13:30:00Z
dc.date.available2024-02-04T13:30:00Z
dc.date.issued2023
dc.identifier.issn2667-663X
dc.identifier.urihttps://doi.org/10.4328/ACAM.21655
dc.identifier.urihttp://hdl.handle.net/11446/4814
dc.description.abstractAim: Diabetes mellitus (DM) is a chronic high blood sugar disorder that can be classified into two groups: type 1 diabetes (T1D) and type 2 diabetes (T2D). The equilibrium between cytokines and chemokines is important for the development and prognosis of the disease. This study aimed to examine the contribution of pro-inflammatory (IL-17, CXCL8, CXCL10) and anti-inflammatory (IL-10, IL-13) factors to the development and prognosis of T1D and T2D. Material and Methods: Cytokine and chemokine levels were evaluated in serum samples of patients with T1D and T2D, and healthy controls. Patients were divided into two groups depending on the history of the disease, as 1-5 years and 5-10 years. HbA1C levels were assessed by HPLC. Concentrations of IL-17, CXCL-8, CXCL-10 and IL-10, IL-13 were analyzed using LUMINEX.Results: A statistically significant difference was observed in the HbA1c levels of all patients versus controls. CXCL8 was increased in patients with T1D compared with the controls. There was a significant difference in IL-13 levels between patients with T1D or T2D over five years and controls. For IL-10 and CXCL-10, there was a significant difference between T1D for more than 5 years and T1D for 5 years or less.Discussion: Cytokines and chemokines are belonging to the immune system, but it is now known that they may also affect non-immune mechanisms. As a result, it is advantageous to take these factors almost equally into account in the diagnosis and treatment of T1D and T2D.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University [TYL-2017-23598]en_US
dc.description.sponsorshipThis study was funded by the Scientific Research Projects Coordination Unit of Istanbul University. Project number: TYL-2017-23598en_US
dc.language.isoengen_US
dc.publisherBayrakol Medical Publisheren_US
dc.relation.ispartofAnnals Of Clinical And Analytical Medicineen_US
dc.identifier.doi10.4328/ACAM.21655
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCytokinesen_US
dc.subjectChemokinesen_US
dc.subjectDiabetesen_US
dc.titleIL-10, IL-13, IL-17 and CXCL8, CXCL10: Their relationship with the development and prognosis of type 1 and type 2 diabetesen_US
dc.typearticleen_US
dc.departmentDBÜen_US
dc.identifier.issue6en_US
dc.identifier.volume14en_US
dc.identifier.startpage541en_US
dc.identifier.endpage545en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-temp[Ebrahimzadeh, Mina; Pehlivanoglu, Cemil; Kucuksezer, Umut Can; Gurol, Ali Osman] Istanbul Univ, Aziz Sancar Inst Expt Med, Dept Immunol, Istanbul, Turkiye; [Ebrahimzadeh, Mina] Istanbul Univ, Inst Hlth Sci, Dept Immunol, Istanbul, Turkiye; [Ozgur, Burcin Aydin] Demiroglu Bilim Univ, Fac Med, Dept Med Biol & Genet, Istanbul, Turkiye; [Degirmencioglu, Sevgin] Kirklareli Univ, Fac Med, Dept Med Biochem, Kirklareli, Turkiye; [Tekin, Sakin] Zonguldak Bulent Ecevit Univ, Dept Endocrinol & Metab, Zonguldak, Turkiye; [Cakmak, Ramazan] Univ Istinye, Hosp Gaziosmanpasa Med Pk, Dept Endocrinol & Metab, Istanbul, Turkiye; [Dirican, Ahmet] Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Dept Biostat, Istanbul, Turkiye; [Gurol, Ali Osman] Istanbul Univ, Diabet Applicat & Res Ctr, Istanbul, Turkiyeen_US
dc.authoridPehlivanoğlu, Cemil/0000-0003-1466-5831
dc.identifier.wosWOS:001019537100014en_US
dc.authorwosidTekin, Sakin/HJP-0599-2023
dc.authorwosidPehlivanoğlu, Cemil/AGQ-5537-2022


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