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The neuro-restorative effect of adipose-derived mesenchymal stem cell transplantation on a mouse model of diabetic neuropathy

dc.contributor.authorYigitturk G.
dc.contributor.authorErbas O.
dc.contributor.authorKarabay Yavasoglu N.U.
dc.contributor.authorAcikgoz E.
dc.contributor.authorBuhur A.
dc.contributor.authorGokhan A.
dc.contributor.authorGurel C.
dc.date.accessioned2024-02-04T13:30:09Z
dc.date.available2024-02-04T13:30:09Z
dc.date.issued2022
dc.identifier.issn01616412
dc.identifier.urihttps://doi.org/10.1080/01616412.2021.1967679
dc.identifier.urihttp://hdl.handle.net/11446/4855
dc.description.abstractDiabetic neuropathy (DN) is the most common degenerative complication associated with Diabetes Mellitus. Despite widespread awareness about DN, the only effective treatments are blood glucose control and pain management. The aim of the current study was to determine the effect of intramuscular adipose-derived mesenchymal stem cell (AMSC) transplantation on sciatic nerves in DN using EMG and histological analyses. A total of 27 mice were randomly divided into three groups: control group, DN group and AMSC group. In EMG, CMAP amplitude in the sciatic nerves was lower, but distal latency was higher in the DN group compared with the control group. CMAP amplitude in the sciatic nerves was higher in the AMSC group compared with the DN group. Distal latency in the sciatic nerve was lower in the AMSC group compared with the DN group. Histologic examination of the tissues in the animals treated with AMSC showed a remarkable improvement in microscopic morphology. Fluorescence microscopy analyses demonstrated that intramuscularly transplanted AMSC was selectively localized in the sciatic nerves. Transplantation of AMSC increased protein expression of S100, cdk2, NGF and DHH, all of which, interfered with DN onset in sciatic nerves. The findings of the present study suggest that AMSC transplantation improved DN through a signal-regulatory effect on Schwann cells, neurotrophic actions and restoration of myelination. © 2021 Informa UK Limited, trading as Taylor & Francis Group.en_US
dc.description.sponsorshipEge University Faculty of Medicine Histology and Embryology Laboratories. We would like to thank Mr.David DUFFY for English language editing.en_US
dc.language.isoengen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofNeurological Researchen_US
dc.identifier.doi10.1080/01616412.2021.1967679
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadipose-derived mesenchymal stem cellen_US
dc.subjectcdk2en_US
dc.subjectdhhen_US
dc.subjectDiabetic neuropathyen_US
dc.subjectemgen_US
dc.subjectngfen_US
dc.subjects100en_US
dc.subjectschwann cellen_US
dc.subjectamphotericin Ben_US
dc.subjectascorbic aciden_US
dc.subjectdexamethasoneen_US
dc.subjectendoglinen_US
dc.subjectglucoseen_US
dc.subjectglutaraldehydeen_US
dc.subjectglycerol 2 phosphateen_US
dc.subjectketamineen_US
dc.subjectpenicillin derivativeen_US
dc.subjectperiodate sodiumen_US
dc.subjectreceptor type tyrosine protein phosphatase Cen_US
dc.subjectstreptomycinen_US
dc.subjectstreptozocinen_US
dc.subjectxylazineen_US
dc.subjectadipose derived stem cellen_US
dc.subjectanalgesiaen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectArticleen_US
dc.subjectawarenessen_US
dc.subjectblood glucose monitoringen_US
dc.subjectcontrolled studyen_US
dc.subjectdemyelinationen_US
dc.subjectdiabetes mellitusen_US
dc.subjectdiabetic neuropathyen_US
dc.subjectedemaen_US
dc.subjectelectromyographyen_US
dc.subjectepididymis faten_US
dc.subjectflow cytometryen_US
dc.subjectfluorescence microscopyen_US
dc.subjectglucose blood levelen_US
dc.subjecthistopathologyen_US
dc.subjectimmunofluorescence assayen_US
dc.subjectimmunoreactivityen_US
dc.subjectmaleen_US
dc.subjectmesenchymal stem cell transplantationen_US
dc.subjectmouseen_US
dc.subjectnonhumanen_US
dc.subjectprotein expressionen_US
dc.subjectSchwann cellen_US
dc.subjectsignal transductionen_US
dc.subjectsubacute careen_US
dc.subjecttransplantationen_US
dc.subjectanimalen_US
dc.subjectdiabetic neuropathyen_US
dc.subjectdisease modelen_US
dc.subjectmesenchymal stem cellen_US
dc.subjectmetabolismen_US
dc.subjectpathophysiologyen_US
dc.subjectsciatic nerveen_US
dc.subjectAnimalsen_US
dc.subjectDiabetic Neuropathiesen_US
dc.subjectDisease Models, Animalen_US
dc.subjectElectromyographyen_US
dc.subjectMaleen_US
dc.subjectMesenchymal Stem Cell Transplantationen_US
dc.subjectMesenchymal Stem Cellsen_US
dc.subjectMiceen_US
dc.subjectSciatic Nerveen_US
dc.titleThe neuro-restorative effect of adipose-derived mesenchymal stem cell transplantation on a mouse model of diabetic neuropathyen_US
dc.typearticleen_US
dc.departmentDBÜen_US
dc.identifier.issue2en_US
dc.identifier.volume44en_US
dc.identifier.startpage156en_US
dc.identifier.endpage164en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-tempYigitturk, G., Department Of Histology And Embryology, Faculty Of Medicine, Muğla Sıtkı Koçman University, Mugla, Turkey; Erbas, O., Department Of Physiology, Faculty Of Medicine, Bilim University, Istanbul, Turkey; Karabay Yavasoglu, N.U., Department Of Biology, Faculty Of Science, Ege University, Izmir, Turkey; Acikgoz, E., Department Of Histology And Embryology, Faculty Of Medicine, Van Yüzüncü Yıl University, Izmir, Turkey; Buhur, A., Department Of Histology And Embryology, Faculty Of Medicine, Ege University, Izmir, Turkey; Gokhan, A., Department Of Histology And Embryology, Faculty Of Medicine, Ege University, Izmir, Turkey; Gurel, C., Department Of Histology And Embryology, Faculty Of Medicine, Ege University, Izmir, Turkey; Gunduz, C., Department Of Medical Biology, Faculty Of Medicine, Ege University, Izmir, Turkey; Yavasoglu, A., Department Of Histology And Embryology, Faculty Of Medicine, Ege University, Izmir, Turkeyen_US
dc.identifier.pmid34410214en_US
dc.identifier.scopus2-s2.0-85113226755en_US
dc.authorscopusid56376463500
dc.authorscopusid55469991100
dc.authorscopusid8633854100
dc.authorscopusid56364984200
dc.authorscopusid57207940063
dc.authorscopusid57219907255
dc.authorscopusid58457608300


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