dc.contributor.author | Erdem E. | |
dc.contributor.author | Karatas A. | |
dc.contributor.author | Ecder T. | |
dc.date.accessioned | 2024-02-04T13:30:13Z | |
dc.date.available | 2024-02-04T13:30:13Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 02535068 | |
dc.identifier.uri | https://doi.org/10.1159/000515639 | |
dc.identifier.uri | http://hdl.handle.net/11446/4869 | |
dc.description.abstract | Introduction: The effect of high serum ferritin levels on long-term mortality in hemodialysis patients is unknown. The relationship between serum ferritin levels and 5-year all-cause mortality in hemodialysis patients was investigated in this study. Methods: A total of 173 prevalent hemodialysis patients were included in this study. The patients were followed for up to 5 years and divided into 3 groups according to time-averaged serum ferritin levels (group 1: Serum ferritin <800 ng/mL, group 2: Serum ferritin 800-1,500 ng/mL, and group 3: Serum ferritin >1,500 ng/mL). Along with the serum ferritin levels, other clinical and laboratory variables that may affect mortality were also included in the Cox proportional-hazards regression analysis. Results: Eighty-one (47%) patients died during the 5-year follow-up period. The median follow-up time was 38 (17.5-60) months. The 5-year survival rates of groups 1, 2, and 3 were 44, 64, and 27%, respectively. In group 3, the survival was lower than in groups 1 and 2 (log-rank test, p = 0.002). In group 1, the mortality was significantly lower than in group 3 (HR [95% CI]: 0.16 [0.05-0.49]; p = 0.001). In group 2, the mortality was also lower than in group 3 (HR [95% CI]: 0.32 [0.12-0.88]; p = 0.026). No significant difference in mortality between groups 1 and 2 was found (HR [95% CI]: 0.49 [0.23-1.04]; p = 0.063). Conclusion: Time-averaged serum ferritin levels >1,500 ng/mL in hemodialysis patients are associated with an increased 5-year all-cause mortality risk. © 2021 S. Karger AG, Basel. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | S. Karger AG | en_US |
dc.relation.ispartof | Blood Purification | en_US |
dc.identifier.doi | 10.1159/000515639 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | End-stage kidney disease | en_US |
dc.subject | Ferritin | en_US |
dc.subject | Hemodialysis | en_US |
dc.subject | Iron | en_US |
dc.subject | Mortality | en_US |
dc.subject | adult | en_US |
dc.subject | all cause mortality | en_US |
dc.subject | article | en_US |
dc.subject | controlled study | en_US |
dc.subject | female | en_US |
dc.subject | ferritin blood level | en_US |
dc.subject | follow up | en_US |
dc.subject | hemodialysis patient | en_US |
dc.subject | human | en_US |
dc.subject | human tissue | en_US |
dc.subject | log rank test | en_US |
dc.subject | major clinical study | en_US |
dc.subject | male | en_US |
dc.subject | protein expression | en_US |
dc.subject | survival rate | en_US |
dc.subject | aged | en_US |
dc.subject | blood | en_US |
dc.subject | chronic kidney failure | en_US |
dc.subject | hemodialysis | en_US |
dc.subject | middle aged | en_US |
dc.subject | mortality | en_US |
dc.subject | proportional hazards model | en_US |
dc.subject | regression analysis | en_US |
dc.subject | ferritin | en_US |
dc.subject | Aged | en_US |
dc.subject | Female | en_US |
dc.subject | Ferritins | en_US |
dc.subject | Follow-Up Studies | en_US |
dc.subject | Humans | en_US |
dc.subject | Kidney Failure, Chronic | en_US |
dc.subject | Male | en_US |
dc.subject | Middle Aged | en_US |
dc.subject | Proportional Hazards Models | en_US |
dc.subject | Regression Analysis | en_US |
dc.subject | Renal Dialysis | en_US |
dc.subject | Survival Rate | en_US |
dc.title | The Relationship between Serum Ferritin Levels and 5-Year All-Cause Mortality in Hemodialysis Patients | en_US |
dc.type | article | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.volume | 51 | en_US |
dc.identifier.startpage | 55 | en_US |
dc.identifier.endpage | 61 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | Erdem, E., Dmed Samsun Dialysis Clinic, Samsun, Turkey; Karatas, A., Department of Nephrology, Ordu University, Faculty of Medicine, Ordu, Turkey; Ecder, T., Department of Nephrology, Demiroglu Bilim University, Faculty of Medicine, Istanbul, Turkey | en_US |
dc.identifier.pmid | 33827077 | en_US |
dc.identifier.scopus | 2-s2.0-85104005139 | en_US |
dc.authorscopusid | 35271904500 | |
dc.authorscopusid | 54902636400 | |
dc.authorscopusid | 6701719246 | |