Gelişmiş Arama

Basit öğe kaydını göster

dc.contributor.authorSahin H.
dc.contributor.authorErbaş O.
dc.date.accessioned2024-02-04T13:30:13Z
dc.date.available2024-02-04T13:30:13Z
dc.date.issued2023
dc.identifier.issn09603271
dc.identifier.urihttps://doi.org/10.1177/09603271231168764
dc.identifier.urihttp://hdl.handle.net/11446/4871
dc.description.abstractBackground: Epilepsy is a common disorder affecting approximately 50 million people worldwide. Oxidative stress is known to play an important role in the pathophysiology of diseases, including epilepsy. In this study, we investigated the effects of sennoside B on PTZ-induced seizures in rats. Method: The rats were grouped into Group Electroencephalography and Group Behavioral. Both Groups were divided into eight subgroups, and these subgroups were compared in terms of the time of first myoclonic jerk, Racine’s Convulsion Scale, malondialdehyde levels, and brain superoxide dismutase activity. The experimental seizure model was performed with pentylenetetrazol. Results: The spike percentage was significantly lower in groups that received sennoside B, and this beneficial effect was shown to be associated with the dose of sennoside B received. The RCS score was lower and the FJM onset time was higher in the sennoside B-administered groups. Additionally, brain MDA and brain aquaporin-3 levels were lower and brain SOD activity was higher in the sennoside-administered groups. Conclusions: The present study shows the beneficial effects of sennoside B on PTZ-induced convulsion in rats. It is considered that sennoside B which is a natural and safe product would be a good candidate for strengthening the management of epilepsy without serious side effects. © The Author(s) 2023.en_US
dc.language.isoengen_US
dc.publisherSAGE Publications Ltden_US
dc.relation.ispartofHuman and Experimental Toxicologyen_US
dc.identifier.doi10.1177/09603271231168764
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAquaporinen_US
dc.subjectepilepsyen_US
dc.subjectexperimentalen_US
dc.subjectsennoside Ben_US
dc.subjectaquaporin 3en_US
dc.subjectmalonaldehydeen_US
dc.subjectpentetrazoleen_US
dc.subjectplaceboen_US
dc.subjectsennoside Ben_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectanticonvulsive agenten_US
dc.subjectpentetrazoleen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectArticleen_US
dc.subjectbrainen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug effecten_US
dc.subjectelectroencephalographyen_US
dc.subjectenzyme activityen_US
dc.subjectenzyme linked immunosorbent assayen_US
dc.subjectlipid peroxidationen_US
dc.subjectnonhumanen_US
dc.subjectpentylenetetrazole-induced convulsionen_US
dc.subjectpentylenetetrazole-induced seizureen_US
dc.subjectraten_US
dc.subjectspikeen_US
dc.subjectadverse eventen_US
dc.subjectanimalen_US
dc.subjectdisease modelen_US
dc.subjectepilepsyen_US
dc.subjectseizureen_US
dc.subjectSprague Dawley raten_US
dc.subjectAnimalsen_US
dc.subjectAnticonvulsantsen_US
dc.subjectDisease Models, Animalen_US
dc.subjectEpilepsyen_US
dc.subjectPentylenetetrazoleen_US
dc.subjectRatsen_US
dc.subjectRats, Sprague-Dawleyen_US
dc.subjectSeizuresen_US
dc.subjectSennosidesen_US
dc.titleBeneficial effects of sennoside B on pentylenetetrazole-induced seizures in ratsen_US
dc.typearticleen_US
dc.departmentDBÜen_US
dc.identifier.volume42en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-tempSahin, H., Department of Emergency, Medical School, Tekirdağ Namık Kemal University, Tekirdag, Turkey; Erbaş, O., Department of Physiology, Medical School, TC Demiroglu Bilim Üniversitesi, İstanbul, Turkeyen_US
dc.identifier.pmid37021362en_US
dc.identifier.scopus2-s2.0-85151796801en_US
dc.authorscopusid55549946700
dc.authorscopusid55469991100


Bu öğenin dosyaları:

DosyalarBoyutBiçimGöster

Bu öğe ile ilişkili dosya yok.

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster