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dc.contributor.authorBora E.S.
dc.contributor.authorErdoğan A.
dc.contributor.authorErdoğan M.A.
dc.contributor.authorYigitturk G.
dc.contributor.authorÇakır A.
dc.contributor.authorErbaş O.
dc.date.accessioned2024-02-04T13:30:16Z
dc.date.available2024-02-04T13:30:16Z
dc.date.issued2022
dc.identifier.issn1306696X
dc.identifier.urihttps://doi.org/10.14744/tjtes.2020.02589
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1137428
dc.identifier.urihttp://hdl.handle.net/11446/4881
dc.description.abstractBACKGROUND: Acute respiratory distress syndrome is a devastating complication of severe sepsis. Preclinical models suggest that direct lung injury begins with attack to the lung epithelium, but indirect lung injury results from systemic endothelial damage due to inflammatory mediators. The aim of the present study was to explore the effect of octreotide on lungs in a surgically induced sepsis model in rats. METHODS: We used 32 male Sprague Dawley rats and divided into four groups. Group 1: Normal (non-operative and orally fed control, n=8); Group 2: Sham operated (n=8); Group 3: Cecal ligation and puncture (CLP) (untreated group, n=8); and Group 4: CLP and 100 µg/kg octreotide i.p. (n=8). For sepsis, CLP procedure was performed on 16 rats to induce a sepsis model. All groups were analyzed, their blood was taken for arterial blood gas analysis. For histological examination, lung tissues were removed and sections were prepared. RESULTS: In histological examination, if we compare CLP + Octreotide with only CLP group in CLP + Octreotide group decreased inflammatory cell infiltration in alveolar and interstitial area as well as edema, bleeding, when CLP group was compared with octreotide group, all histopathological parameters improved significantly and the severity index decreased from 3 to 1. For arterial blood gas, when CLP and octreotide groups were compared with CLP group, it was observed that there was a significant change in favor of healing and that they almost came up to controls and sham group. CONCLUSION: It could be hypothesized that it would be beneficial to administer octreotide for ameliorate lung injury state in sepsis patients. © 2022, Turkish Association of Trauma and Emergency Surgery. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherTurkish Association of Trauma and Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma ve Acil Cerrahi Dergisien_US
dc.identifier.doi10.14744/tjtes.2020.02589
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute respiratory distress syndromeen_US
dc.subjecthistopathologyen_US
dc.subjectoctreotideen_US
dc.subjectsepsisen_US
dc.subjectketamineen_US
dc.subjectoctreotideen_US
dc.subjectoctreotideen_US
dc.subjectadult respiratory distress syndromeen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectarterial gasen_US
dc.subjectArticleen_US
dc.subjectblood gas analysisen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug effecten_US
dc.subjectexperimental sepsisen_US
dc.subjectforced expiratory volumeen_US
dc.subjecthistopathologyen_US
dc.subjectlactate blood levelen_US
dc.subjectlaparotomyen_US
dc.subjectlung alveolusen_US
dc.subjectlung epitheliumen_US
dc.subjectlung parenchymaen_US
dc.subjectlung resectionen_US
dc.subjectmaleen_US
dc.subjectnonhumanen_US
dc.subjectraten_US
dc.subjectSprague Dawley raten_US
dc.subjectacute lung injuryen_US
dc.subjectanimalen_US
dc.subjectcecumen_US
dc.subjectcomplicationen_US
dc.subjectdisease modelen_US
dc.subjecthumanen_US
dc.subjectligationen_US
dc.subjectlungen_US
dc.subjectsepsisen_US
dc.subjectsurgeryen_US
dc.subjectAcute Lung Injuryen_US
dc.subjectAnimalsen_US
dc.subjectCecumen_US
dc.subjectDisease Models, Animalen_US
dc.subjectHumansen_US
dc.subjectLigationen_US
dc.subjectLungen_US
dc.subjectMaleen_US
dc.subjectOctreotideen_US
dc.subjectRatsen_US
dc.subjectRats, Sprague-Dawleyen_US
dc.subjectSepsisen_US
dc.titleShort-term protective effect of octreotide on the lungs of rats with experimentally induced sepsisen_US
dc.title.alternativeOktreotidin, sepsis modelinde sıçanların akciğerleri üzerindeki kısa dönem koruyucu etkisien_US
dc.typearticleen_US
dc.departmentDBÜen_US
dc.identifier.issue1en_US
dc.identifier.volume28en_US
dc.identifier.startpage8en_US
dc.identifier.endpage14en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-tempBora, E.S., Department Emergency Medicine, İzmir Katip Çelebi University Atatürk Training and Research Hospital, İzmir, Turkey; Erdoğan, A., Department Emergency Medicine, İzmir Çiğli Regional Training Hospital, İzmir, Turkey; Erdoğan, M.A., Department of Physiology, İzmir Katip Çelebi University Faculty of Medicine, İzmir, Turkey; Yigitturk, G., Department of Histology and Embryology, Muğla Sıtkı Koçman University Faculty of Medicine, Muğla, Turkey; Çakır, A., Department Emergency Medicine, İzmir Katip Çelebi University Atatürk Training and Research Hospital, İzmir, Turkey; Erbaş, O., Department of Physiology, İstanbul Demiroğlu Bilim University Facutly of Medicine, İstanbul, Turkeyen_US
dc.identifier.pmid34967421en_US
dc.identifier.scopus2-s2.0-85123049254en_US
dc.authorscopusid55672440000
dc.authorscopusid57202425103
dc.authorscopusid57189713929
dc.authorscopusid56376463500
dc.authorscopusid57222041711
dc.authorscopusid55469991100
dc.identifier.trdizinid1137428en_US


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