dc.contributor.author | Özkul B. | |
dc.contributor.author | Sever İ.H. | |
dc.contributor.author | Yiğittürk G. | |
dc.contributor.author | Elgörmüş Ç.S. | |
dc.contributor.author | Gür S.G. | |
dc.contributor.author | Erbaş O. | |
dc.date.accessioned | 2024-02-04T13:30:16Z | |
dc.date.available | 2024-02-04T13:30:16Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 1306696X | |
dc.identifier.uri | https://doi.org/10.14744/tjtes.2023.73580 | |
dc.identifier.uri | http://hdl.handle.net/11446/4882 | |
dc.description.abstract | BACKGROUND: Our target was to show the role of high mobility group box-1/receptor for (HMGB1/RAGE) interaction in feces intraperitoneal injection procedure (FIP)-induced acute lung injury (ALI) pathophysiology, to investigate the effect of papaverine on RAGE associated NF-?B pathway by determining the level of soluble RAGE (sRAGE) and HMGB1, and to support this hypothesis by evaluating inflammatory biochemical, oxidative stress markers, Hounsfield unit (HU) value in computed tomography (CT), and histopathological results. METHODS: FIP was performed on 37 Wistar rats for creating a sepsis-induced ALI model. The animals were assigned into four groups as follows: Normal control (no treatment), placebo (FIP and saline), and receiving 20 mg/kg and 40 mg/kg per day papaverine. Twenty h after FIP, CT examination was performed for all animals, and HU value of the lung parenchyma was measured. The plasma levels of tumor necrosis factor (TNF)-?, HMGB1, sRAGE, C-reactive protein (CRP) and malondialdehyde (MDA), and lactic acid (LA) were determined and PaO2 and PaCO2 were measured from arterial blood sample. Lung damage was assessed by histopathological. RESULTS: TNF-, IL-6, CRP, HMGB1, MDA, LA levels, histopathologic scores, and HU values of CT were significantly increased and sRAGE levels were decreased in the saline-treated group against normal group (all P<0.05). Papaverine significantly reversed all results regardless of the dose (all P<0.05) and demonstrated inhibition of HMGB1/RAGE interaction through increasing sRAGE levels and suppresses the pro-inflammatory cytokines. CONCLUSION: We concluded that papaverine has ameliorating effects in rat model of ALI. © 2023, Turkish Association of Trauma and Emergency Surgery. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Turkish Association of Trauma and Emergency Surgery | en_US |
dc.relation.ispartof | Ulusal Travma ve Acil Cerrahi Dergisi | en_US |
dc.identifier.doi | 10.14744/tjtes.2023.73580 | |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Acute lung injury | en_US |
dc.subject | HMGB-1 | en_US |
dc.subject | inflammation | en_US |
dc.subject | papaverine | en_US |
dc.subject | RAGE | en_US |
dc.subject | sepsis | en_US |
dc.subject | advanced glycation end product receptor | en_US |
dc.subject | C reactive protein | en_US |
dc.subject | high mobility group B1 protein | en_US |
dc.subject | lactic acid | en_US |
dc.subject | malonaldehyde | en_US |
dc.subject | papaverine | en_US |
dc.subject | thiobarbituric acid reactive substance | en_US |
dc.subject | tumor necrosis factor | en_US |
dc.subject | C reactive protein | en_US |
dc.subject | high mobility group B1 protein | en_US |
dc.subject | lactic acid | en_US |
dc.subject | papaverine | en_US |
dc.subject | adult | en_US |
dc.subject | alveolar wall thickness | en_US |
dc.subject | animal experiment | en_US |
dc.subject | animal model | en_US |
dc.subject | animal tissue | en_US |
dc.subject | Article | en_US |
dc.subject | biochemical analysis | en_US |
dc.subject | bleeding | en_US |
dc.subject | blood carbon dioxide tension | en_US |
dc.subject | blood oxygen tension | en_US |
dc.subject | blood sampling | en_US |
dc.subject | cardiac puncture | en_US |
dc.subject | computer assisted tomography | en_US |
dc.subject | controlled study | en_US |
dc.subject | drug efficacy | en_US |
dc.subject | edema | en_US |
dc.subject | enzyme linked immunosorbent assay | en_US |
dc.subject | feces intraperitoneal injection | en_US |
dc.subject | histology | en_US |
dc.subject | histopathology | en_US |
dc.subject | hounsfield unit | en_US |
dc.subject | inflammation | en_US |
dc.subject | injection | en_US |
dc.subject | interstitial edema | en_US |
dc.subject | lipid oxidation | en_US |
dc.subject | lung parenchyma | en_US |
dc.subject | male | en_US |
dc.subject | molecular interaction | en_US |
dc.subject | NF kB signaling | en_US |
dc.subject | nonhuman | en_US |
dc.subject | oxidative stress | en_US |
dc.subject | parameters | en_US |
dc.subject | perivascular edema | en_US |
dc.subject | rat | en_US |
dc.subject | rat model | en_US |
dc.subject | sepsis-induced acute lung injury | en_US |
dc.subject | thickness | en_US |
dc.subject | acute lung injury | en_US |
dc.subject | animal | en_US |
dc.subject | radiology | en_US |
dc.subject | sepsis | en_US |
dc.subject | Wistar rat | en_US |
dc.subject | Acute Lung Injury | en_US |
dc.subject | Animals | en_US |
dc.subject | C-Reactive Protein | en_US |
dc.subject | HMGB1 Protein | en_US |
dc.subject | Lactic Acid | en_US |
dc.subject | Papaverine | en_US |
dc.subject | Radiology | en_US |
dc.subject | Rats | en_US |
dc.subject | Rats, Wistar | en_US |
dc.subject | Sepsis | en_US |
dc.title | Demonstration of ameliorating effect of papaverine in sepsis-induced acute lung injury on rat model through radiology and histology | en_US |
dc.title.alternative | Papaverinin sepsis kaynaklı akut akciğer hasarında iyileştirici etkisinin sıçan modelinde radyoloji ve histoloji yoluyla gösterilmesi | en_US |
dc.type | article | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.volume | 29 | en_US |
dc.identifier.startpage | 963 | en_US |
dc.identifier.endpage | 971 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | Özkul, B., Department of Radiology, İstanbul Atlas University, İstanbul, Turkey; Sever, İ.H., Department of Radiology, Demiroğlu Bilim University, İstanbul, Turkey; Yiğittürk, G., Department of Histology and Embryology, Muğla Sıtkı Koçman University, Muğla, Turkey; Elgörmüş, Ç.S., Department of Emergency, İstanbul Atlas University, İstanbul, Turkey; Gür, S.G., Department of Radiology, Acıbadem Group, Bursa, Turkey; Erbaş, O., Department of Physiology, Demiroğlu Bilim University, İstanbul, Turkey | en_US |
dc.identifier.pmid | 37681716 | en_US |
dc.identifier.scopus | 2-s2.0-85170180961 | en_US |
dc.authorscopusid | 56604118900 | |
dc.authorscopusid | 57299310900 | |
dc.authorscopusid | 56376463500 | |
dc.authorscopusid | 57299311000 | |
dc.authorscopusid | 57528554000 | |
dc.authorscopusid | 55469991100 | |