Advanced Search

Show simple item record

dc.contributor.authorTatar, Burak Ergün
dc.contributor.authorUyanıkgil, Yiğit
dc.contributor.authorLineaweaver, William
dc.contributor.authorAkdemir, Ovunc
dc.contributor.authorErbaş, Oytun
dc.contributor.authorZhang, Feng
dc.date.accessioned2024-02-04T13:30:30Z
dc.date.available2024-02-04T13:30:30Z
dc.date.issued2023
dc.identifier.issn2602-3741
dc.identifier.urihttps://doi.org/10.54005/geneltip.1181620
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1180179
dc.identifier.urihttp://hdl.handle.net/11446/4941
dc.description.abstractObjective Ischemia-reperfusion (I/R) injury is tissue damage occurring when blood returns to a tissue after an ischemic phase. Reperfusion initiates a cascade of acute inflammatory processes that end in cell death, tissue malfunction, and necrosis. Edaravone (3-methy-1-pheny1-2-pyrazolin-5-one) is a powerful and unique synthetic radical scavenger. In this research, the effects of edaravone on I/R damage were investigated. Material and Methods: 16 adult male Sprague–Dawley rats were utilized. Eight rats were allocated at random into two groups. Group 1 (the control group) experienced ischemia and reperfusion of an abdominal skin flap for 10 hours without therapy. Group 2 (treatment group) received an intraperitoneal injection of 3 mg/kg edaravone 10 hours prior to ischemia and reperfusion in an abdominal skin flap. Using planimetry, flaps were examined at intervals of 1, 3, 7, and 10 days. Then, flaps were removed for biochemical (measurement of tissue glutathione [GSH], tissue protein, lipid peroxidation [MDA], and nitric oxide [NO] levels) and histopathological (measurement of tissue glutathione [GSH], tissue protein, lipid peroxidation [MDA], and nitric oxide [NO] levels) Results: We found no significant changes (p > 0.05) between groups 1 and 2 in terms of NO, MDA, GSH, or planimetric analyses. Group 2 had a lower neutrophil count than group 1, however the difference was not statistically significant (p > 0.05). Conclusion Edaravone is a very effective antioxidant. Nevertheless, our research indicates that it may not influence I/R damage in a skin flap model.en_US
dc.language.isoengen_US
dc.relation.ispartofGenel Tıp Dergisien_US
dc.identifier.doi10.54005/geneltip.1181620
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titlePreventive Effect of Edaravone Against Ischemia-Reperfusion Injury in Rat Epigastric Island Flaps: An Experimental Studyen_US
dc.typearticleen_US
dc.departmentDBÜen_US
dc.identifier.issue2en_US
dc.identifier.volume33en_US
dc.identifier.startpage117en_US
dc.identifier.endpage122en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-tempBağcılar Eğitim ve Araştırma Hastanesi, Plastik Cerrahi Bölümü, İstanbul, Türkiye Ege Üniversitesi, Histoloji Bölümü ve Embriyoloji, İzmir, Türkiye Joseph M. Still Burn and Reconstructive Center, 346 Crossgates Blvd, Suite 202, Brandon, MS, U.S.A Ovunç Akdemir Klinikleri, Plastik Cerrahi Kliniği, İstanbul, Türkiye Demiroğlu Bilim Üniversitesi, Fizyoloji Bölümü, İstanbul, Türkiye Joseph M. Still Burn and Reconstructive Center, 346 Crossgates Blvd, Suite 202, Brandon, MS, U.S.Aen_US
dc.identifier.trdizinid1180179en_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record