dc.contributor.author | Eygi, E. | |
dc.contributor.author | Kucuk, O. | |
dc.contributor.author | Aydemir, S. | |
dc.contributor.author | Atilgan, M. | |
dc.contributor.author | Dokuyucu, R. | |
dc.contributor.author | Erbas, O. | |
dc.date.accessioned | 2025-01-12T18:55:02Z | |
dc.date.available | 2025-01-12T18:55:02Z | |
dc.date.issued | 2024 | |
dc.identifier.issn | 1010-660X | |
dc.identifier.uri | https://doi.org/10.3390/medicina60111791 | |
dc.identifier.uri | http://hdl.handle.net/11446/5044 | |
dc.description.abstract | Background and Objectives: It is known that critical illness and associated neuromuscular problems begin to appear in patients hospitalized in the intensive care unit (ICU) for more than a week. The goal of this study was to research the role of hydroxychloroquine (HCQ) in the treatment of cytokine storm and critical illness neuromyopathy (CINM) in a rat sepsis model. Materials and Methods: Rats were assigned into three groups, and a feces intraperitoneal-injection group (FIP) procedure was carried out on 30 rats to induce a model of sepsis for critical illness polyneuromyopathy (CINM). The study groups were as follows: Group 1: control (nonoperative and orally fed control, n = 10), Group 2: FIP with 0.9% NaCl saline was given as 1 mL/kg/day by oral gavage (n = 10), and Group 3: FIP with 10 mg/kg/day of hydroxychloroquine (Plaquenil 200 mg) administered by oral gavage (n = 10). Electrophysiological recordings (EMG) were conducted six days after surgery. EMG was carried out three times on the right sciatic nerve, which was stimulated with supramaximal intensity utilizing a bipolar needle electrode at the sciatic notch. Tumor necrosis factor-alpha (TNF-?), malondialdehyde (MDA), lactic acid levels, and interleukin-6 (IL-6) were evaluated. Results: In terms of TNF-?, MDA, lactic acid levels, and IL-6, there was a statistically significant decrease in the CINM + 10 mg/kg HCQ group compared to the CINM and saline group (p < 0.0001, p < 0.05, p < 0.05, and p < 0.05, respectively). Compound muscle action potentials (CMAPs) latency and duration were decreased in the CINM + 10 mg/kg HCQ group compared to other groups (p < 0.01 and p < 0.001). However, CMAP amplitude was significantly higher in the CINM + 10 mg/kg HCQ group unlike the CINM and saline group (p < 0.001). Conclusions: This is the first study to demonstrate the effects of HCQ on CINM in a rat model of sepsis. The findings of our research suggest that hydroxychloroquine may be used as a potential therapeutic agent in the treatment of sepsis. Hydroxychloroquine may have an important effect in the pathogenesis of sepsis-associated CINM by reducing cytokine production and oxidative stress. © 2024 by the authors. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | en_US |
dc.relation.ispartof | Medicina (Lithuania) | en_US |
dc.identifier.doi | 10.3390/medicina60111791 | |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | critical illness neuromyopathy | en_US |
dc.subject | hydroxychloroquine | en_US |
dc.subject | interleukin-6 | en_US |
dc.subject | malondialdehyde | en_US |
dc.subject | muscle action potential | en_US |
dc.subject | tumor necrosis factor-alpha | en_US |
dc.subject | Animals | en_US |
dc.subject | Critical Illness | en_US |
dc.subject | Cytokine Release Syndrome | en_US |
dc.subject | Disease Models, Animal | en_US |
dc.subject | Electromyography | en_US |
dc.subject | Hydroxychloroquine | en_US |
dc.subject | Male | en_US |
dc.subject | Polyneuropathies | en_US |
dc.subject | Rats | en_US |
dc.subject | Sepsis | en_US |
dc.subject | hydroxychloroquine | en_US |
dc.subject | animal | en_US |
dc.subject | complication | en_US |
dc.subject | critical illness | en_US |
dc.subject | cytokine release syndrome | en_US |
dc.subject | disease model | en_US |
dc.subject | drug therapy | en_US |
dc.subject | electromyography | en_US |
dc.subject | etiology | en_US |
dc.subject | male | en_US |
dc.subject | pathophysiology | en_US |
dc.subject | polyneuropathy | en_US |
dc.subject | rat | en_US |
dc.subject | sepsis | en_US |
dc.title | Hydroxychloroquine Mitigates Cytokine Storm and Prevents Critical Illness Neuromyopathy in a Rat Sepsis Model | en_US |
dc.type | article | en_US |
dc.department | DBÜ | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.volume | 60 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.department-temp | Eygi E., Department of Anesthesiology and Reanimation, Gaziantep City Training and Research Hospital, Gaziantep, 27470, Turkey; Kucuk O., Department of Anesthesiology and Reanimation, Ankara Atatürk Sanatorium Training and Research Hospital, University of Health Sciences, Ankara, 06000, Turkey; Aydemir S., Department of Anesthesiology and Reanimation, Yenimahalle Training and Research Hospital, University of Yıldırım Beyazit, Ankara, 06370, Turkey; Atilgan M., Department of Pediatric Surgery, School of Medicine, Necmettin Erbakan University, Konya, 42140, Turkey; Dokuyucu R., Department of Physiology, Medical Specialization Training Center (TUSMER), Ankara, 06230, Turkey; Erbas O., Department of Physiology, School of Medicine, Demiroglu Bilim University, Istanbul, 34570, Turkey | en_US |
dc.identifier.pmid | 39596976 | en_US |
dc.identifier.scopus | 2-s2.0-85210425640 | en_US |
dc.authorscopusid | 59143370300 | |
dc.authorscopusid | 58620424100 | |
dc.authorscopusid | 55199369200 | |
dc.authorscopusid | 57219530110 | |
dc.authorscopusid | 55567414500 | |
dc.authorscopusid | 55469991100 | |