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dc.contributor.authorEygi, E.
dc.contributor.authorKucuk, O.
dc.contributor.authorAydemir, S.
dc.contributor.authorAtilgan, M.
dc.contributor.authorDokuyucu, R.
dc.contributor.authorErbas, O.
dc.date.accessioned2025-01-12T18:55:02Z
dc.date.available2025-01-12T18:55:02Z
dc.date.issued2024
dc.identifier.issn1010-660X
dc.identifier.urihttps://doi.org/10.3390/medicina60111791
dc.identifier.urihttp://hdl.handle.net/11446/5044
dc.description.abstractBackground and Objectives: It is known that critical illness and associated neuromuscular problems begin to appear in patients hospitalized in the intensive care unit (ICU) for more than a week. The goal of this study was to research the role of hydroxychloroquine (HCQ) in the treatment of cytokine storm and critical illness neuromyopathy (CINM) in a rat sepsis model. Materials and Methods: Rats were assigned into three groups, and a feces intraperitoneal-injection group (FIP) procedure was carried out on 30 rats to induce a model of sepsis for critical illness polyneuromyopathy (CINM). The study groups were as follows: Group 1: control (nonoperative and orally fed control, n = 10), Group 2: FIP with 0.9% NaCl saline was given as 1 mL/kg/day by oral gavage (n = 10), and Group 3: FIP with 10 mg/kg/day of hydroxychloroquine (Plaquenil 200 mg) administered by oral gavage (n = 10). Electrophysiological recordings (EMG) were conducted six days after surgery. EMG was carried out three times on the right sciatic nerve, which was stimulated with supramaximal intensity utilizing a bipolar needle electrode at the sciatic notch. Tumor necrosis factor-alpha (TNF-?), malondialdehyde (MDA), lactic acid levels, and interleukin-6 (IL-6) were evaluated. Results: In terms of TNF-?, MDA, lactic acid levels, and IL-6, there was a statistically significant decrease in the CINM + 10 mg/kg HCQ group compared to the CINM and saline group (p < 0.0001, p < 0.05, p < 0.05, and p < 0.05, respectively). Compound muscle action potentials (CMAPs) latency and duration were decreased in the CINM + 10 mg/kg HCQ group compared to other groups (p < 0.01 and p < 0.001). However, CMAP amplitude was significantly higher in the CINM + 10 mg/kg HCQ group unlike the CINM and saline group (p < 0.001). Conclusions: This is the first study to demonstrate the effects of HCQ on CINM in a rat model of sepsis. The findings of our research suggest that hydroxychloroquine may be used as a potential therapeutic agent in the treatment of sepsis. Hydroxychloroquine may have an important effect in the pathogenesis of sepsis-associated CINM by reducing cytokine production and oxidative stress. © 2024 by the authors.en_US
dc.language.isoengen_US
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)en_US
dc.relation.ispartofMedicina (Lithuania)en_US
dc.identifier.doi10.3390/medicina60111791
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcritical illness neuromyopathyen_US
dc.subjecthydroxychloroquineen_US
dc.subjectinterleukin-6en_US
dc.subjectmalondialdehydeen_US
dc.subjectmuscle action potentialen_US
dc.subjecttumor necrosis factor-alphaen_US
dc.subjectAnimalsen_US
dc.subjectCritical Illnessen_US
dc.subjectCytokine Release Syndromeen_US
dc.subjectDisease Models, Animalen_US
dc.subjectElectromyographyen_US
dc.subjectHydroxychloroquineen_US
dc.subjectMaleen_US
dc.subjectPolyneuropathiesen_US
dc.subjectRatsen_US
dc.subjectSepsisen_US
dc.subjecthydroxychloroquineen_US
dc.subjectanimalen_US
dc.subjectcomplicationen_US
dc.subjectcritical illnessen_US
dc.subjectcytokine release syndromeen_US
dc.subjectdisease modelen_US
dc.subjectdrug therapyen_US
dc.subjectelectromyographyen_US
dc.subjectetiologyen_US
dc.subjectmaleen_US
dc.subjectpathophysiologyen_US
dc.subjectpolyneuropathyen_US
dc.subjectraten_US
dc.subjectsepsisen_US
dc.titleHydroxychloroquine Mitigates Cytokine Storm and Prevents Critical Illness Neuromyopathy in a Rat Sepsis Modelen_US
dc.typearticleen_US
dc.departmentDBÜen_US
dc.identifier.issue11en_US
dc.identifier.volume60en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-tempEygi E., Department of Anesthesiology and Reanimation, Gaziantep City Training and Research Hospital, Gaziantep, 27470, Turkey; Kucuk O., Department of Anesthesiology and Reanimation, Ankara Atatürk Sanatorium Training and Research Hospital, University of Health Sciences, Ankara, 06000, Turkey; Aydemir S., Department of Anesthesiology and Reanimation, Yenimahalle Training and Research Hospital, University of Yıldırım Beyazit, Ankara, 06370, Turkey; Atilgan M., Department of Pediatric Surgery, School of Medicine, Necmettin Erbakan University, Konya, 42140, Turkey; Dokuyucu R., Department of Physiology, Medical Specialization Training Center (TUSMER), Ankara, 06230, Turkey; Erbas O., Department of Physiology, School of Medicine, Demiroglu Bilim University, Istanbul, 34570, Turkeyen_US
dc.identifier.pmid39596976en_US
dc.identifier.scopus2-s2.0-85210425640en_US
dc.authorscopusid59143370300
dc.authorscopusid58620424100
dc.authorscopusid55199369200
dc.authorscopusid57219530110
dc.authorscopusid55567414500
dc.authorscopusid55469991100


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