Hepatocellular Cancer and Liver Transplantation; Is There Any Novelty in Prognostic Factors For Survival and Recurrence?

Abstract

Objectives: Hepatocellular cancer constitutes 75-85% of liver cancers, and its treatment requires a multidisciplinary approach. Milan criteria are golden standart candidate selection criteria that ensure excellent posttransplant survival and follow up with low recurrence rate. However, other classifications include histopathological features or biological behaviors may vary survival and recurrence. We examined the parameters that may have prognostic value in our study. Material and Methods: 217 patients for recurrence, 226 patients for overall survival, 48 patients for disease free survival, whose explant pathology is hepatocellular carcinoma and data information can be obtained were evaluated. Recurrence and overall survival and disease free survival were statistically analyzed in terms of age, gender, living and cadaveric transplanted patient groups, blood group, BMİ, MELD and Child scores, Milan criteria and pathological parameters. All survival rates were evaluated in terms of recurrent organ location, number of organ recurrence, and survival rates. Results: There were less recurrence rates in patients, with 0 blood group, inside milan criteria, with less total and maximum tumor diameter. It was also observed that the maximum tumor size affected the overall survival multivariately It was observed that survival was worse in early recurrence and recurrence in the first 24 months. Conclusion: İt is observed that being inside the milan and tumor diameter affect the recurrence and survival, surgery to be performed in localized recurrences and additional systemic treatment will affect survival positively.