dc.contributor.author | Kürtüncü, Murat | |
dc.contributor.author | Kaya, Dilaver | |
dc.contributor.author | Zuliani, Luigi | |
dc.contributor.author | Erdağ, Ece | |
dc.contributor.author | İçöz, Sema | |
dc.contributor.author | Uğurel, Elif | |
dc.contributor.author | Tüzün, Erdem | |
dc.date.accessioned | 2014-11-12T08:43:33Z | |
dc.date.available | 2014-11-12T08:43:33Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Kurtuncu M, Kaya D, Zuliani L, Erdag E, Içoz S, Ugurel E, Cavus F, Aysit N, Birisik O, Vincent A, Eraksoy M, Vural B, Akman-Demir G, Tuzun E. CACNA1H antibodies associated with headache with neurological deficits and cerebrospinal fluid lymphocytosis (HaNDL). Cephalalgia. 2013; 33(2): 123-129. doi: 10.1177/0333102412463494. | en_US |
dc.identifier.issn | 0333-1024 | |
dc.identifier.uri | http://cep.sagepub.com/content/33/2/123.long#corresp-1 | en_US |
dc.identifier.uri | https://hdl.handle.net/11446/529 | en_US |
dc.description | İstanbul Bilim Üniversitesi, Tıp Fakültesi. | en_US |
dc.description.abstract | Background: Patients with the syndrome of headache with neurological deficits and lymphocytosis (HaNDL) typically present with recurrent and temporary attacks of neurological symptoms and cerebrospinal fluid lymphocytosis.
Aim and methods: To identify potential HaNDL-associated antibodies directed against neuronal surface and/or synapse antigens, sera of four HaNDL patients and controls were screened with indirect immunohistochemistry, immunofluorescence, cell-based assay, radioimmunoassay, protein macroarray and enzyme-linked immunosorbent assay (ELISA).
Results: Although HaNDL sera did not yield antibodies to any of the well-characterized neuronal surface or synapse antigens, protein macroarray and ELISA studies showed high-titer antibodies to a subunit of the T-type voltage-gated calcium channel (VGCC), CACNA1H, in sera of two HaNDL patients.
Conclusion: Our results support the notion that ion channel autoimmunity might at least partially contribute to HaNDL pathogenesis and occurrence of neurological symptoms | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Sage Publications Ltd. | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | HaNDL | en_US |
dc.subject | headache | en_US |
dc.subject | CACNA1H | en_US |
dc.subject | voltage-gated calcium channel | en_US |
dc.subject | autoantibody | en_US |
dc.title | CACNA1H antibodies associated with headache with neurological deficits and cerebrospinal fluid lymphocytosis (HaNDL) | en_US |
dc.type | article | en_US |
dc.relation.journal | Cephalalgia | en_US |
dc.department | DBÜ, Tıp Fakültesi | en_US |
dc.identifier.issue | 2 | |
dc.identifier.volume | 33 | |
dc.identifier.startpage | 123 | |
dc.identifier.endpage | 129 | |
dc.contributor.authorID | TR101668 | en_US |
dc.contributor.authorID | TR207129 | en_US |
dc.contributor.authorID | TR126262 | en_US |
dc.contributor.authorID | TR24384 | en_US |
dc.contributor.authorID | TR156716 | en_US |
dc.relation.publicationcategory | Belirsiz | en_US |