Coexistence of Hashimoto’s Thyroiditis With Papillary Thyroid Carcinoma and Its Effects on Prognosis

Abstract

Thyroiditis is a general term that includes various diseases characterized by inflammation of the thyroid gland. Hashimoto’s thyroiditis is the most common autoimmune thyroid disease and its incidence has been increasing in recent years. Papillary thyroid cancer is the most common thyroid cancer, and it is more common with HT than in the general population. Since the relationship between Hashimoto’s thyroiditis and papillary thyroid cancer was first put forward by Dailey et al. in 1955, discussions and research on this issue still continue. The incidence of co-occurrence of Hashimoto’s thyroiditis and papillary thyroid cancer varies between 0.5% and 41.4% according to the literature, and the mean age has been found lower. It has been reported that the combination of Hashimoto’s thyroiditis and papillary thyroid cancer has a protective effect, papillary thyroid cancer with Hashimoto’s thyroiditis is less aggressive, the tumor is smaller and more often multifocal, and has less lymph node invasion. Papillary thyroid cancer related gene activations in dysplastic thyrocyte groups observed in multifocal areas in the background of Hashimoto’s thyroiditis may be responsible for Hashimoto’s thyroiditis- papillary thyroid cancer association and multifocality.

Tiroidit, tiroid glandinin inflamasyonu ile karakterize, çesitli hastaliklari içeren genel bir terimdir. Hashimoto tiroiditi, en sik görülen otoimmun tiroid hastaligidir ve son yillarda insidansi giderek artmaktadir. Papiller tiroid kanseri ise en sik görülen tiroid kanseri olup Hashimo tiroiditi zemininde genel popülasyona göre daha sik görülmektedir. Hashimoto tiroiditi ile papiller tiroid karsinomu arasindaki iliski ilk olarak 1955 yilinda Dailey ve ark tarafindan ortaya atildigindan beri bununla ilgili tartismalar ve arastirmalar hala devam etmektedir. Hashimoto tiroiditi ve papiller tiroid karsinomu birlikte görülme insidansi literatüre göre %0.5 ile %41.4 arasinda degismekte olup ortalama yas daha düsük bulunmustur. Hashimoto tiroiditi ve papiller tiroid karsinom birlikteliginin koruyucu bir etki gösterdigi, Hashimoto tiroiditi ile birlikte olan papiller tiroid karsinomunun daha az agresif, tümörün daha küçük ve daha siklikla multifokal oldugu, daha az lenf nod invazyonu gösterdigi bildirilmistir. Hashimoto tiroiditi zemininde, multifokal alanlarda izlenen, displastik tirosit gruplarindaki papiller tiroid karsinomu iliskili gen aktivasyonlari, Hashimoto tiroiditi-papiller tiroid karsinom birlikteligi ve multifokaliteden sorumlu tutulabilir.noz, Tiroidit.