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dc.contributor.authorKıyat-Atamer, Aslı
dc.contributor.authorEkizoğlu, E
dc.contributor.authorTüzün, Erdem
dc.contributor.authorKürtüncü, Murat
dc.contributor.authorShugaiv, Erkingül
dc.contributor.authorDemir-Akman, Gülşen
dc.contributor.authorEraksoy, Mefkure
dc.date.accessioned2014-11-12T09:27:31Z
dc.date.available2014-11-12T09:27:31Z
dc.date.issued2013
dc.identifier.citationKiyat-Atamer A, Ekizoglu E, Tuzun E, Kurtuncu M, Shugaiv E, Akman-Demir G, Eraksoy M. Long-term MRI findings in neuromyelitis optica: seropositive versus seronegative patients. European Journal of Neurology. 2013; 20(5): 781-7. doi: 10.1111/ene.12058.en_US
dc.identifier.issn1351-5101
dc.identifier.urihttp://onlinelibrary.wiley.com/en_US
dc.identifier.urihttps://hdl.handle.net/11446/532en_US
dc.descriptionİstanbul Bilim Üniversitesi, Tıp Fakültesi.en_US
dc.description.abstractBackground and purpose Neuromyelitis optica (NMO) is a severe demyelinating inflammatory disorder associated with serum antibodies against aquaporin 4 (AQP4-Ab). A significant number of patients with NMO remain seronegative over time. Long-term observational magnetic resonance imaging (MRI) studies of the CNS in patients with NMO are rare or of limited duration. The objective of this study is to determine long-term MRI characteristics of seropositive and seronegative patients, and assess possible overlap with multiple sclerosis (MS). Methods Clinical and radiological characteristics of 28 patients with NMO at onset and of 17 patients after an average follow-up time of 9years were recorded. Fifty percent of patients were seropositive for AQP4-Ab. Onset and final brain/spinal MRI scans were retrospectively analysed and compared. Results Significantly more patients in the seronegative group had brain lesions at onset. Spinal lesions of seropositive patients were longer and showed increased cord swelling at onset MRI scans. After the follow-up time the differences between both groups disappeared. Patients in the seropositive group tended to develop brain lesions over time. No patient fulfilled Barkhof's or McDonald's radiological criteria for MS at onset or over time. Conclusion Brain MRI features show differences between seropositive and seronegative patients at time of onset in NMO, but differences between groups vanish over time. None of the AQP4-negative patients fulfill radiological MS criteria on a long-term basis, suggesting that seronegative NMO constitutes an independent entity.en_US
dc.language.isoengen_US
dc.publisherWiley-Blackwellen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectaquaporin 4 seropositivityen_US
dc.subjectaquaporin-4en_US
dc.subjectmagnetic resonance imagingen_US
dc.subjectneuromyelitis opticaen_US
dc.subjectNMO IgGen_US
dc.titleLong-term MRI findings in neuromyelitis optica: Seropositive versus seronegative patientsen_US
dc.typearticleen_US
dc.relation.journalEuropean Journal of Neurologyen_US
dc.departmentDBÜ, Tıp Fakültesien_US
dc.identifier.issue5
dc.identifier.volume20
dc.identifier.startpage781
dc.identifier.endpage787
dc.relation.publicationcategoryBelirsizen_US


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