Mitochondrial carrier homolog 1 (Mtch1) antibodies in neuro-behcet's disease
MetadataShow full item record
CitationVural B, Sehitoglu E, Cavus F, Yalçınkaya N, Haytural H, Kuçukerden M, Ulusoy C, Ugurel E, Turan S, Bulut L, Turkoglu R, Shugaiv E, Kurtuncu M, Atakan S, Gure AO, Gul A, Eraksoy M, Akman-Demir G, Tuzun E. Mitochondrial carrier homolog 1 (Mtch1) antibodies in neuro-Behçet's disease. Journal of Neuroimmunology. 2013; 263(1-2): 139-44. doi: 10.1016/j.jneuroim.2013.08.007.
Efforts for the identification of diagnostic autoantibodies for neuro-Behcet's disease (NBD) have failed. Screening of NBD patients' sera with protein macroarray identified mitochondrial carrier homolog 1 (Mtch1), an apoptosis-related protein, as a potential autoantigen. ELISA studies showed serum Mtch1 antibodies in 68 of 144 BD patients with or without neurological involvement and in 4 of 168 controls corresponding to a sensitivity of 47.2% and specificity of 97.6%. Mtch1 antibody positive NBD patients had more attacks, increased disability and lower serum nucleosome levels. Mtch1 antibody might be involved in pathogenic mechanisms of NBD rather than being a coincidental byproduct of autoinflammation.
SourceJournal of Neuroimmunology