KARACIGER BIYOPSI ILE NONALKOLIK YAGLI KARACIGER HASTALIGI TANISI ALAN 220 HASTANIN RETROSPEKTIF DEGERLENDIRILMESI

Abstract

Non alkolik yagli karaciger hastalgi (NAYKH) alkol tüketimi olmadan karaciger yaglanmasi olarak tanimlanir. NAYKH, dünyada en sik görülen kronik karaciger hastaligi olarak bilinir. NAYKH, siroz ve hepatoselüler kanser gibi ciddi hastaliklara sebep olabilmektedir. Bu çalismada karaciger biyopsisi ile NAYKH tanisi alan 220 hastayi retrospektif olarak degerlendirmeyi amaçladik. Arastirmaya 2010-2019 yillari arasinda Demiroglu Bilim Üniversitesi Tip Fakültesi gastroenteroloji polikliniginde takip edilen karaciger biyopsi ile NAYKH tanisi alan toplam 220 hasta alindi. Olgularin demografik (yas, cinsiyet, boy, kilo, beden kitle indeksi (BMI), laboratuvar (biyokimyasal parametreler) ve biyopsi sonuçlari hastane bilgi sisteminden ve dosyalarindan retrospektif olarak toplandi. Hastalarin yas ortalamasi 34.14 ± 6.72 ve % 60’i erkek, % 40’i kadindi. Erkek ve kadin hastalarda karaciger yaglanma yüzdesi ortalamasi benzerdi (p: 0.41). Hastalarin BMI ortalamasi: 27.32 ± 3.02, ortalama karaciger steatoz yüzdesi % 12.1 ± 8.68 ve ortalama Homeostatic Model of Assessment-Insulin Resistance (HOMA-IR) degeri 2.64 saptandi. Yaglanma derecesi ile BMI, aspartat aminotransferaz, alanin aminotransferaz, alkalen fosfataz, gamaglutamil transferaz, total kolesterol, trigliserit , kreatinin ve HOMA-IR arasinda pozitif korelasyon saptanirken yas, üre ve total biluribin ile herhangi bir korelasyon belirlenmedi. Çalismamizda genç ve orta yas grubu ile obez olmayan kisilerde de NAYKH görülebilecegi, BMI ve insülin direncinin bu hasta grubunda da NAYKH ile iliskili olabilecegi gözlendi. Ayrica, karaciger enzimleri normal aralikta olsa bile NAYKH ile iliskili olabilecekleri görülmüstür. Yeni ve daha genis kapsamli çalismalarla, bu konuda daha güvenilir veriler elde edilebilecegi düsünülmektedir.

Non-alcoholic fatty liver disease (NAFLD) defined as fatty accumulation in liver without alcohol consumption. NAFLD is known as the most common chronic liver disease worldwide. NAFLD can cause serious diseases such as cirrhosis and hepatocellular cancer (HCC). We aimed to evaluate retrospectively 220 liver biopsy proven patients with NAFLD in this study. A total of 220 patients diagnosed with NAFLD by liver biopsy followed in the gastroenterology outpatient clinic of Demiroglu Bilim University Faculty of Medicine between 2010-2019 were included in the study. Demographic data (age, gender, height, weight and body mass index), biochemical laboratory parameters and biopsy results were scanned and recorded retrospectively from hospital information system and files of patients. The mean age of the patients was 34.14 ± 6.72 and 60% of the patients were male and 40% were female. Mean liver steatosis percentage was similar in male and female patients (p: 0.41). The mean BMI of the patients was 27.32 ± 3.02, the mean liver steatosis percentage was 12.1 ± 8.68% and the mean Homeostatic Model of Assessment-Insulin Resistance (HOMA-IR) value was 2.64. There was a positive correlation between liver steatosis and BMI, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamaglutamyl transferase, total cholesterol, triglyceride, creatinine and HOMA-IR, but no correlation was found between liver steatosis and age, urea and bilirubin. In our study, it was observed that NAFLD can be seen in young and middle-aged, non-obese individuals, and BMI and insulin resistance may be associated with NAFLD in this patient group. In addition, liver enzymes were found to be associated with NAFLD even if they were in the normal range. More reliable data can be obtained with new and more extensive studies.