dc.contributor.author | Shugaiv, Erkingül | |
dc.contributor.author | Leite, Maria Isabel | |
dc.contributor.author | Şehitoğlu, Elçin | |
dc.contributor.author | Woodhall, Mark | |
dc.contributor.author | Çavuş, Filiz | |
dc.contributor.author | Waters, Patrick | |
dc.contributor.author | Tüzün, Erdem | |
dc.date.accessioned | 2014-11-26T09:32:43Z | |
dc.date.available | 2014-11-26T09:32:43Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Shugaiv , Leite MI, Sehitoglu E, Woodhall M, Cavus F, Waters P, Icoz S, Birisik O, Ugurel E, Ulusoy C, Kurtuncu M, Vural B, Vincent A, Akman-Demir G, Tuzun E. Progressive encephalomyelitis with rigidity and myoclonus: a syndrome with diverse clinical features and antibody responses. European Neurology. 2013; 69(5): 257-262.
doi: 10.1159/000342237. | en_US |
dc.identifier.issn | 0014-3022 | |
dc.identifier.uri | http://www.karger.com/Article/FullText/342237 | en_US |
dc.identifier.uri | https://hdl.handle.net/11446/549 | en_US |
dc.description | İstanbul Bilim Üniversitesi, Tıp Fakültesi. | en_US |
dc.description.abstract | Background/Aims: To better characterize progressive encephalomyelitis with rigidity and myoclonus (PERM) syndrome and identify novel PERM phenotypes. Methods: The clinical features and antibody status of PERM patients were investigated using immunoblots, cell-based assays, RIA, protein macroarray and ELISA. Results: Two patients with supratentorial involvement showed abnormal PET or EEG findings. One patient was discovered to have renal cell carcinoma, and protein macroarray revealed Ma3-antibodies. Another patient with leucine-rich, glioma-inactivated 1 (LGI1) and glutamic acid decarboxylase (GAD) antibodies showed a good response to immunotherapy. Conclusion: The heterogeneity of the immunological features suggests that PERM is caused by diverse pathogenic mechanisms. Seropositivity to well-characterized neuronal cell surface antigens might indicate a good treatment response | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Karger AG, Basel | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | progressive encephalomyelitis with rigidity and myoclonus | en_US |
dc.subject | autoimmune encephalitis | en_US |
dc.subject | paraneoplastic | en_US |
dc.subject | protein macroarray | en_US |
dc.subject | antibody | en_US |
dc.subject | autoimmunity | en_US |
dc.title | Progressive encephalomyelitis with rigidity and myoclonus: A syndrome with diverse clinical features and antibody responses | en_US |
dc.type | article | en_US |
dc.relation.journal | European Neurology | en_US |
dc.department | DBÜ, Tıp Fakültesi | en_US |
dc.identifier.issue | 5 | |
dc.identifier.volume | 69 | |
dc.identifier.startpage | 257 | |
dc.identifier.endpage | 262 | |
dc.contributor.authorID | TR198421 | en_US |
dc.contributor.authorID | TR101668 | en_US |
dc.contributor.authorID | TR47341 | en_US |
dc.contributor.authorID | TR24384 | en_US |
dc.contributor.authorID | TR156716 | en_US |
dc.relation.publicationcategory | Belirsiz | en_US |