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dc.contributor.authorAkman, Ozlem
dc.contributor.authorOnat, Filiz
dc.date.accessioned2025-10-06T06:30:20Z
dc.date.available2025-10-06T06:30:20Z
dc.date.issued2025
dc.identifier.issn2470-9239
dc.identifier.urihttps://doi.org/10.1002/epi4.70075
dc.identifier.urihttp://hdl.handle.net/11446/5500
dc.description.abstractAbsence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike-and-wave discharges (SWDs). Traditionally attributed to cortico-thalamo-cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological framework involving high-order thalamic nuclei, the basal ganglia, limbic structures, and the cerebellum. Rather than arising abruptly from a discrete cortical event, SWDs appear to develop progressively through dynamic network interactions. This paradigm shift underscores the necessity of a network-based approach to comprehensively understand AS pathophysiology. Concurrently, advances in electrophysiology and neuroimaging are refining our understanding of the signaling mechanisms that drive AS generation. This review explores the network dynamics underlying AS, synthesizing recent experimental and clinical findings to provide an integrative framework for future research and the development of novel therapeutic strategies in absence epilepsy.Plain Language SummaryAbsence seizures are brief episodes of staring and unresponsiveness, often beginning in childhood, and are caused by abnormal rhythmic activity in the brain. This review summarizes recent research on how specific brain circuits generate and maintain these seizures. While most studies have focused on the cortex and thalamus, we also highlight the contributions of other regions such as the basal ganglia, cerebellum, and limbic structures. Understanding how these brain networks interact may help explain seizure patterns and guide the development of improved treatments.en_US
dc.description.sponsorshipEuropean Commission Horizon Europe Programme under the call HORIZON-WIDERA-2021-ACCESS-03 [HORIZON-WIDERA-2021-ACCESS-03, 101078981-GEMSTONE]; European Commission Horizon Europe Programmeen_US
dc.description.sponsorshipThe work, performed in the Filiz Onat's laboratory, was funded by the European Commission Horizon Europe Programme under the call HORIZON-WIDERA-2021-ACCESS-03 [Grant Number 101078981-GEMSTONE].en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEpilepsia Openen_US
dc.identifier.doi10.1002/epi4.70075
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbasal gangliaen_US
dc.subjectcerebellumen_US
dc.subjectidiopathic generalized epilepsiesen_US
dc.subjectlimbic systemen_US
dc.subjectspike-and-wave dischargesen_US
dc.titleAbsence seizures: Update on signaling mechanisms and networksen_US
dc.typearticleen_US
dc.departmentDBÜen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.department-temp[Akman, Ozlem] Demiroglu Bilim Univ, Sch Med, Dept Physiol, Istanbul, Turkiye; [Onat, Filiz] Acibadem Mehmet Ali Aydinlar Univ, Sch Med, Dept Med Pharmacol, Istanbul, Turkiye; [Onat, Filiz] Acibadem Mehmet Ali Aydinlar Univ, Inst Hlth Sci, Dept Neurosci, Istanbul, Turkiyeen_US
dc.identifier.pmid40522613en_US
dc.identifier.scopus2-s2.0-105008412567en_US
dc.identifier.wosWOS:001508689700001en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ2en_US
dc.snmzKA_WOS_20251006
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US


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