dc.contributor.author | Oktar, Tayfun | |
dc.contributor.author | Koçak, Taner | |
dc.contributor.author | Öner-İyidoğan, Yıldız | |
dc.contributor.author | Erdem, Selçuk | |
dc.contributor.author | Seyithanoğlu, Muhammed | |
dc.contributor.author | Ziylan, Orhan | |
dc.contributor.author | Koçak, Hikmet | |
dc.date.accessioned | 2014-11-26T09:36:30Z | |
dc.date.available | 2014-11-26T09:36:30Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Oktar T, Kocak T, Oner-Iyidogan Y, Erdem S, Seyithanoglu M, Ziylan O, Kocak H. Urinary nerve growth factor in children with overactive bladder: a promising, noninvasive and objective biomarker. Journal of Pediatric Urology. 2013; 9(5): 617-621. doi: 10.1016/j.jpurol.2012.06.003. | en_US |
dc.identifier.issn | 1477-5131 | |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S1477513112001593 | en_US |
dc.identifier.uri | https://hdl.handle.net/11446/550 | en_US |
dc.description | İstanbul Bilim Üniversitesi, Tıp Fakültesi. | en_US |
dc.description.abstract | Objective: This prospective study was designed to determine urinary nerve growth factor (NGF) levels in children with overactive bladder (OAB), and to evaluate whether this factor can be used as a biomarker for diagnosis and monitoring treatment outcome.
Patients and methods: Urinary NGF levels were determined in 40 children with OAB and in a control group of 20 children with no urinary symptoms. Urine samples were collected from the patients prior to and at 3 and 6 months after the beginning of treatment. The total NGF levels (pg/mL) were further normalized to the concentration of urinary creatinine (NGF/Cr level).
Results: Overall, both NGF and NGF/Cr levels were significantly higher at the beginning of the study. Mean NGF levels were 30.75 +/- 8.35 and 9.75 +/- 2.11 pg/ml (p=0.023) and mean NGF/Cr levels were 0.53 +/- 0.14 and 0.16 +/- 0.04 (p = 0.022) in patients and controls, respectively. After 6 months of therapy, the NGF/Cr level was significantly reduced to almost control levels (0.16 +/- 0.02, p = 0.047).
Conclusion: NGF and NGF/Cr levels were significantly higher in children with OAB than controls at initial evaluation. Furthermore, the NGF/Cr level was significantly reduced following 6 months of therapy. NGF and NGF/Cr levels show promise as reliable biomarkers for OAB diagnosis and to monitor therapy in the pediatric age group | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | urinary nerve growth factor | en_US |
dc.subject | overactive bladder | en_US |
dc.subject | biomarker | en_US |
dc.title | Urinary nerve growth factor in children with overactive bladder: A promising, noninvasive and objective biomarker | en_US |
dc.type | article | en_US |
dc.relation.journal | Journal of Pediatric Urology | en_US |
dc.department | DBÜ, Tıp Fakültesi | en_US |
dc.identifier.issue | 5 | |
dc.identifier.volume | 9 | |
dc.identifier.startpage | 617 | |
dc.identifier.endpage | 621 | |
dc.contributor.authorID | TR199781 | en_US |
dc.contributor.authorID | TR41505 | en_US |
dc.contributor.authorID | TR168225 | en_US |
dc.contributor.authorID | TR167867 | en_US |
dc.contributor.authorID | TR55972 | en_US |
dc.contributor.authorID | TR31001 | en_US |
dc.relation.publicationcategory | Belirsiz | en_US |