Pleomorphic carcinoma of the lung with high serum beta-human chorionic gonadotropin level and gynecomastia
Demir, Osman Gökhan
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CitationOkutur K, Hasbal B, Aydin K, Bozkurt M, Namal E, Oz B, Kaynak K, Demir G. Pleomorphic carcinoma of the lung with high serum beta-human chorionic gonadotropin level and gynecomastia. Korean Academy of Medical Sciences. 2010; 25(12): 1805-8. doi: 10.3346/jkms.2010.25.12.1805.
INTRODUCTION Pleomorphic carcinoma of the lung is defined as a group of poorly differentiated non-small cell carcinoma that contains a component of sarcoma or sarcoma-like elements and shows carcinomatous as well as spindle and/or giant cell components . Pleomorphic component should comprise at least 10% of neoplasm. It's a rare tumor that makes up only 0.1% to 0.4% of all malignant lung tumors, and its clinical prognosis is highly unpredictable [2-4].Elevated serum beta-human chorionic gonadotropin (βhCG) levels have been reported in 12% of NSCLC patients . When immunohistochemical methods are used, βhCG positivity have been detected in 28% of the resected specimens . Although βhCG production is not seen rarely in NSCLC, clinically significant symptoms, e.g. gynecomastia are uncommon. Here we describe a 50-yr-old male patient with pulmonary pleomorphic carcinoma producing high levels of βhCG and presenting with gynecomastia.